Encephalitides, an acute infection of the brain parenchyma, are characterized by fever, headache and altered consciousness. Neurological deficits and focal or generalized epileptic seizures may also be seen. There are important differences in clinical presentations between encephalitides caused by viruses. While some viral encephalitides, such as Herpes simplex virus type-1 (HSV type-1) encepha...

Herpes simplex virus infection of the central nervous system is still a significant cause of morbidity and often mortality. Changes of central nervous system are results of primary infection or activation of latent HSV-1, HSV-2. Neurological deficits often follow encephalitis herpetica. The application of PCR is prompt and specific diagnosis of herpes simplex virus infections of the brain. Adva...

The interaction of Herpes Simplex Virus type 1 (HSV-1) with human fetal foreskin fibroblast (HFFF) cell was studied using a recent isolate of HSV-1 which was propagated in Hep-2 cells. HFFF cells were challenged with HSV-1 with a multiplicity of infection (MOI) of 1 virus/cell for 24 hours. Flow cytometric analysis demonstrated that HSV-1 challenged HFFF cells expressed increased levels of α2β1...

Herpes Simplex Virus type 1 (HSV-1) is usually the cause of oral infection. This infection oftenprecedes development this chronic anemia, and it reasonable that blood in circulation through virusinfectedtissue becomes contaminated with virus particles on red cell surface. These virus-contaminated redblood cells may stimulate reticuloendothelial system to produce antibodies destroy andlead anemi...

HERPES SIMPLEX VIRUS TYPE 2 (HSV-2) seroprevalence has increased by 32% in the last decade. Overall, HSV-2 seroprevalence is 22% in the general US adult population, and in some populations, such as sexually transmitted disease (STD) clinic attendees, seroprevalence varies between 30% and 50%. Concomitant with this increase in genital herpes has been an increase in reported cases of neonatal her...

Herpes simplex virus (HSV) is an enveloped double-stranded DNA virus that is a common pathogen in humans. There are 2 subtypes, HSV-1 and HSV-2, which are distinguished by their different DNA composition. Their nucleic acids demonstrate approximately 50% base sequence homology.1 The subtypes also differ in a surface glycoprotein, gG: HSV-1 has gG1 and HSV-2 has gG2; they form the basis of type-...

We report the case of a 23-year-old male burn patient with an unusual herpes simplex virus (HSV) skin manifestation. The clinical symptoms and results of HSV type 1 (HSV-1) UL23 polymorphism analysis from saliva and lesional skin underscores the need for performing molecular analysis of HSV-1 infections in burned patients presenting unusual skin lesions.

Fattiviracin A1, showed potent antiviral activities against herpes simplex virus type 1 (HSV-1), varicella-zoster virus (VZV), influenza A virus and human immunodeficiency virus type 1 (HIV-1). It showed no cytotoxicity against Vero cells. Fattiviracin A1 exhibited no significant antibacterial or antifungal activities. Treatment of HSV-1 with fattiviracin A1 decreased its infectivity to Vero ce...

Subjects with oral herpes lesions at the time of serum sampling had higher-efficiency antibody (higher proportion of neutralizing antibody as determined by plaque reduction, compared with total antibody as detected by radioimmunoassay) to herpes simplex virus type 1 (HSV-1) than did subjects with no lesions at the time of serum sampling. These higher-efficiency sera also had higher antibody tit...