Mouse thymic virus (MTLV; ICTV designation murid herpesvirus 3) infects developing T lymphocytes of neonatal mice, causing thymic necrosis and acute immunosuppression. Infected animals shed virus indefinitely. In the present report, two-color flow cytometric analysis of T lymphocyte subpopulations defined by the markers CD4 (L3T4) and CD8 (Lyt-2) was used to determine whether MTLV was lytic for...

patients with multiple myeloma and Waldenstrom’s macroglobulinemia. Blood 91:4393, 1998 15. Brousset P, Meggetto F, Attal M, Delsol G: Kaposi’s sarcomaassociated herpesvirus infection and multiple myeloma. Science 278: 1972, 1997 16. Beksac M, Ma M, DerDanielian M, Zhang L, Liu J, Kuzu I, Erekul S, Vescio R, Berenson J: Frequent demonstration of human nerpesvirus 8 (HHV-8) in bone marrow sample...

patients with multiple myeloma and Waldenstrom’s macroglobulinemia. Blood 91:4393, 1998 15. Brousset P, Meggetto F, Attal M, Delsol G: Kaposi’s sarcomaassociated herpesvirus infection and multiple myeloma. Science 278: 1972, 1997 16. Beksac M, Ma M, DerDanielian M, Zhang L, Liu J, Kuzu I, Erekul S, Vescio R, Berenson J: Frequent demonstration of human nerpesvirus 8 (HHV-8) in bone marrow sample...

Kaposi's sarcoma-associated herpesvirus (KSHV) or human herpesvirus-8 (HHV-8) is a newly identified herpesvirus. KSHV is an important pathogen capable of causing disease that affects all age groups worldwide. KSHV is etiologically associated with all forms of Kaposi's sarcoma (KS), body cavity lymphomas, and multicentric Castleman disease (MCD). The use of highly active antiretroviral therapy (...

RF: HHV-8 and multiple myeloma in the UK. Lancet 350:1144, 1997 (letter) 7. Gao S-J, Alsina M, Deng J-H, Harrison CR, Montalvo EA, Leach CT, Roodman GD, Jenson HB: Antibodies to Kaposi’s sarcomaassociated herpesvirus (human herpesvirus 8) in patients with multiple myeloma. J Infect Dis 178:846, 1998 8. Basten A, Brink R, Peake P, Adams E, Crosbie J, Hartley S, Goodnow CC: Self tolerance in the ...

RF: HHV-8 and multiple myeloma in the UK. Lancet 350:1144, 1997 (letter) 7. Gao S-J, Alsina M, Deng J-H, Harrison CR, Montalvo EA, Leach CT, Roodman GD, Jenson HB: Antibodies to Kaposi’s sarcomaassociated herpesvirus (human herpesvirus 8) in patients with multiple myeloma. J Infect Dis 178:846, 1998 8. Basten A, Brink R, Peake P, Adams E, Crosbie J, Hartley S, Goodnow CC: Self tolerance in the ...

amyotrophic lateral sclerosis is a progressive neurodegenerative disease with uncertain etiology. for many years, viruses have been suspected as causative agents. there are conflicting reports about the possible role of viruses such as human herpes virus 8 (hhv8) and retroviruses in the pathogenesis of the sporadic amyotrophic lateral sclerosis. we conducted a prospective case-control study to ...

Fas- and tumor necrosis factor receptor 1 (TNFR1)-induced apoptosis is mediated by the interaction of FADD with caspase-8. Here, we report that the bovine herpesvirus 4 (BHV4) BORFE2 gene encodes a protein that inhibits Fas- and TNFR1-induced apoptosis and contains death effector domains (DEDs). Using the yeast two-hybrid system, we found that the BORFE2 protein interacts with the prodomain of ...