Nicotine administration (2.5 mg/kg of body weight, sc, 5 days a week for 22 weeks) enhanced lipid peroxidative indices (thiobarbituric acid reactive substances and hydroperoxides) accompanied by a significant increase in the marker enzymes alanine transaminase, aspartate transaminase, alkaline phosphatase and lactate dehydrogenase and elevated levels of cholesterol, triglycerides, phospholipids...

The pharmacological effects on the central nervous system (CNS) of a range of available flavonoid glycosides were explored and compared to those of the glycosides 2S-hesperidin and linarin, recently isolated from valeriana. The glycosides 2S-neohesperidin, 2S-naringin, diosmin, gossipyn and rutin exerted a depressant action on the CNS of mice following i.p. injection, similar to that found with...

Acrylonitrile (ACN) is a volatile, toxic liquid used as a monomer in the manufacture of synthetic rubber, styrene plastics, acrylic fiber, and adhesives. ACN is a potent neurotoxin. A role for free radical mediated lipid peroxidation in the toxicity of ACN has been suggested. We examined the ability of hesperidin, an antioxidant flavonoid, to attenuate ACN-induced alterations in lipid peroxidat...

Background and objectives: A key aspect of cisplatin-induced hepatotoxicity is oxidative stress. The current study was conducted to show, for the first time, the restoring and synergistic effects of morin and hesperidin against oxidative stress in hepatotoxicity. Methods: Fourty-two Wistar albino rats were randomly divided into seven groups: group A (control), ...

Free radical formation from flavonoids by peroxidase action and changes in flavonoid levels and peroxidase activity during storage were determined to clarify the involvement of naringin radical in chlorophyll (Chl) degradation in stored green Nagato-yuzukichi (Citrus nagato-yuzukichi hort. ex Y. Tanaka) fruit. Chl a was degraded by peroxidase-hydrogen peroxide system not in the presence of hesp...

Aims The aim of the study was to evaluate the effect of 10% sodium ascorbate (SA),10% hesperidin, 1% riboflavin 5-phosphate, collagen cross-linkers, on the pushout bond strength of the fiber resin postluted to the radicular dentin. Materials and Methods Twenty-eight, single-rooted extracted human teeth were collected. The cleaning shaping and obturation was done followed postspace preparation...

Citrus bioflavonoids may offer some protection against the early stage of diabetes mellitus and the development of complications. We investigated the effect of hesperidin on blood glucose levels, hepatic glucose-regulating enzyme activities, serum insulin and adiponectin levels, serum and hepatic lipid levels, and parameters of bone loss in streptozotocin (STZ)-induced marginal type 1 diabetic ...

The aim of this research was to prepare the inclusion complexes formed by hesperidin and (2-hydroxypropyl)-β-cyclodextrin by different techniques (kneading, co-evaporation and lyophilization methods), to carry out phase solubility studies, in vitro dissolution, antioxidant and antimicrobial tests. To confirm the inclusion compounds formation, spectroscopic (UV-Vis, FTIR, 1 H-NMR) and thermal (D...

This study stems from observations made on a number of poliomyelitis patients treated with hesperidin and ascorbic acid (Hesper-C‡) five years ago as a prophylactic measure to maintain normal capillary integrity. We originally treated 48 patients, ranging in age from 15 to 35 years, with 800 mg. each of hesperidin and ascorbic acid daily, to correct capillary fragility, and then continued these...