Despite diagnostic, preventive and therapeutic advances, growing incidence of cancer and high rate of mortality among patients affected by specific cancer types indicate current clinical measures are not ideally useful in eradicating cancer. Chemoresistance and subsequent disease relapse are believed to be mainly driven by the cell-molecular heterogeneity of human tumors that necessitates perso...

Opening up is often considered a commitment to breaking indigenous firms’ status quo and moving the institutional reforms forward. However, the institutional environment in many open countries has yet to show the sign of improvement. We suggest that one important reason for the various reactions to openness is firm heterogeneity. Economic policies have different effects on different firms, and ...

This study aims to develop motorcycle ownership and usage models with consideration of the state dependence and heterogeneity effects based on a large-scale questionnaire panel survey on vehicle owners. To account for the independence among alternatives and heterogeneity among individuals, the modeling structure of motorcycle ownership adopts disaggregate choice models considering the multinomi...

OBJECTIVE Describing and analysing the Spanish Parliamentary debate on immigration and health. METHODS A systematic search regarding parliamentary initiatives (PI) on immigration and immigration and health was conducted from the beginning of the Spanish democratic period (1979 to 2007). A protocol for collecting information was used to identify the parliamentary debate's main characteristics ...

Inter-individual heterogeneity is evident in aging; education level is known to contribute for this heterogeneity. Using a cross-sectional study design and network inference applied to resting-state fMRI data, we show that aging was associated with decreased functional connectivity in a large cortical network. On the other hand, education level, as measured by years of formal education, produce...

This paper presents a model of nation formation in which culturally heterogeneous agents vote on the optimal level of public spending. Larger nations beneÞt from increasing returns in the provision of public goods, but bear the costs of greater cultural heterogeneity. This tradeoff induces agents’ preferences over different geographical conÞgurations, thus determining the likelihood of secessio...

This note extends Strulovici (2010) to the case where voter types are correlated and/or ex ante heterogeneous. There are two voters and the risky action is taken according to the unanimity rule. Increasing correlation between the types of the two voters reduces the negative payoff externality that voters have on each other, thereby increases experimentation and efficiency. Moreover, it allows v...

OBJECTIVES This systematic review and meta-analysis provides a quantitative summary of the literature exploring the relationship between maternal diet quality during pregnancy and child cognitive and affective outcomes. We investigate whether there are indications for robust associations and aim to identify methodological strengths and challenges of the current research to provide suggestions o...

We propose tests of the two assumptions under which anchoring vignettes identify heterogeneity in reporting of categorical evaluations. Systematic variation in the perceived difference between any two vignette states is sufficient to reject vignette equivalence. Response consistency - the respondent uses the same response scale to evaluate the vignette and herself - is testable given sufficient...