Effects of nicotine on the delayed gastric contraction due to vagal afferent stimulation were studied. Cats were pretreated with phentolamine (2 mg/kg, i.v.) and propranolol (1 mg/kg, i.v.). The delayed contraction was inhibited by nicotine (100 to 2000 micrograms/kg, i.v.) in a dose-dependent manner. The inhibition of the delayed contraction by nicotine was blocked by hexamethonium (20 mg/kg, ...

This paper is concerned with the effect of exercise on the blood pressure and the modification of this effect by hexamethonium bromide. It is well known that the methonium compounds can produce a fall in the blood pressure ofmany hypertensive subjects when lying down. This fall, however, is variable and inconstant. In normal persons, the methonium compounds do not produce a fall in the basal bl...

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Antihypertensive drug treatment is capable of aggravating angina pectoris in hypertensive patients with coronary artery disease. The complication appears to be due to different hemodynamic mechanisms. Angina pectoris caused by hydralazine may result not only from a reduction in aortic perfusion pressure but also from increases in cardiac output and pulse rate which the drug produces. Coronary i...

Although nicotinic acetylcholine receptors in both the central and peripheral nervous systems play a prominent role in the control of urinary bladder function, little is known regarding expression or function of nicotinic receptors in the bladder epithelium, or urothelium. Nicotinic receptors have been described in epithelial cells lining the upper gastrointestinal tract, respiratory tract, and...

We studied the involvement of periventricular and hypothalamic angiotensinergic and cholinergic pathways in osmotically induced arginine vasopressin (AVP) release into the blood. In conscious Wistar rats, i.c.v. injections of 0.2, 0.3 and 0.6 M hyperosmolar saline (5 microl) resulted in concentration-dependent increases in AVP release (5.2 +/- 1.5, 10.6 +/- 2.2 and 18.0 +/- 2.2 pg/ml, respectiv...