Since two closely related gene isolates of a novel flavivirus, designated hepatitis G virus (HGV) and hepatitis GB virus C (GBV-C), respectively, were first identified (2, 3), 11 HGV/ GBV-C-related gene sequences have been reported. We report here a gene sequence for the envelope 1 (E1) region of an HGV/GBV-C strain obtained from a Japanese patient who had positive titers for HGV, HCV, and HBV....

Organizational knowledge management (KM) research studies the nature of knowledge, the scope of KM, the factors and mechanisms that affect KM outcomes, as well as theoretical KM frameworks. This paper discusses the implications of past studies for the KM efforts in the human genetic variation (HGV) research domain and presents a HGV-KM research model. This model identifies the context of HGV KM...

The genome of a recently identified virus, hepatitis G virus (HGV), shows considerable homology to hepatitis C virus (HCV). Two HGV proteases similar to nonstructural proteins NS2 and NS3 of HCV were identified, and their cleavage site specificity was investigated. Amino acids essential for the protease activities were determined by mutation analysis. NS4A of HGV was demonstrated to be a cofact...

The novel flavivirus GB virus C/hepatitis G virus (GBV-C/HGV) has been detected in approximately 2% of blood donors in the United States, and neutralizing antibody to the envelope protein (E2), a marker of previous infection with GBV-C/HGV, is present in approximately 9% of donors. The rate of GBV-C/HGV infection among American children is unknown. To determine whether viral infection might occ...

Hepatitis G virus (HGV)/GB virus-C (GBV-C) has been identified as a blood-borne agent with disputed pathogenicity. This virus belongs to the flaviviridae with a distant relationship to hepatitis C virus (HCV). Genetically divergent HGV isolates have been reported from different parts of the world. This study describes the prevalence of HGV in multitransfused thalassaemic children in India and g...

The distribution of Hepatitis GB-C/HG (GB-C/HG) and TT viruses (TTV) infections was investigated in selected populations from Gabon using Polymerase Chain Reaction (PCR) and Enzyme Linked Immunosorbent Assay (ELISA) for anti-Envelop 2 (anti-E2) GBV-C/HGV antibodies. Among pregnant women, 29 of 229 (12.6%) were Hepatitis GB virus-C and Hepatitis G virus (GBV-C/HGV) RNA positive (+) and 32 of 81 ...

To study mother-to-infant transmission of GB virus C/hepatitis G virus (GBV-C/HGV), blood samples of infants born to carrier mothers were collected beginning 3 months after birth and were tested for GBV-C/HGV RNA until 1 year of age. Of 2046 mothers, 2.1% were positive for GBV-C/HGV RNA, and 25 of their infants were followed for a median of 12 months. Thirteen infants (52%) were viremic, and in...

As little is known about liver histology in the co-infection of hepatitis C virus (HCV) and hepatitis G virus (HGV), HGV RNA was investigated in 46 blood donors with hepatitis C, 22 of them with liver biopsy: co-infection HCV / HGV (n = 6) and HCV isolated infection (n = 16). Besides staging and grading of inflammation at portal, peri-portal and lobular areas (Brazilian Consensus), the fibrosis...

BACKGROUND The etiology and the natural history of acute non A-E hepatitis is still undefined. METHODS We examined the prevalence of HGV viraemia and the long-term outcome in 54 patients with non A-E acute hepatitis. RESULTS HGV-RNA was found in 19 out of 54 (35%) patients. There was no difference between HGV-RNA positives and negatives in terms of age sex, parenteral risk factors and alani...