Long-range chromosomal associations between genomic regions, and their repositioning in the 3D space of the nucleus, are now considered to be key contributors to the regulation of gene expression and important links have been highlighted with other genomic features involved in DNA rearrangements. Recent Chromosome Conformation Capture (3C) measurements performed with high throughput sequencing ...

Moran, Daniel S., Luba Eli-Berchoer, Yuval Heled, Liran Mendel, Mara Schocina, and Michal Horowitz. Heat intolerance: does gene transcription contribute? J Appl Physiol 100: 1370–1376, 2006. First published December 15, 2005; doi:10.1152/japplphysiol.01261.2005.— During exertion in the heat, heat-intolerant (HI) subjects have a physiological disability in metabolic heat dissipation. The HI stat...

Tumor-initiating cells (T-ICs) discovered in various tumors have been widely reported. However, T-IC populations in salivary gland tumors have yet to be elucidated. Using the established Pleomorphic Adenoma Gene-1 (Plag1) transgenic mouse model of a salivary gland tumor, we identified CD44(high) (CD44(hi)) tumor cells, characterized by high levels of CD44 cell surface expression, as the T-ICs f...

Gene-gene interaction (GGI) plays an important role in the causation of complex diseases, and its importance has now been well recognized through the findings of many successful genome-wide association studies (GWAS). Although many statistical methods have been introduced to address GGI analysis in GWAS, these methods have mainly focused on two-way interactions, rather than on high-order intera...

In this study, we addressed the role of tumor necrosis factor (TNF)-alpha and lymphotoxin (LT)-alpha in the development of colitis and defined the cellular sources (T cells versus non-T cells) of TNF (TNF-alpha and LT-alpha) relevant to disease development. After adoptive transfer of TNF(+/+) CD4(+)CD45RB(hi) splenocytes into TNF(+/+) recombination activating gene (RAG)2(-/-) mice, the recipien...

The effects of stress (threat of shock) on GSR nonspecific responses were evaluated for Ss who differed in transitory anxiety as measured by the Affect Adjective Check List (AACL). 52 Ss were equally divided among 4 groups: Hi AACL Stress, Lo AACL Stress, Hi AACL Nonstress, and Lo AACL Nonstress. First, all Ss rested; then both Stress groups were threatened with shock, while both Nonstress grou...

Much has been learned about calculation, commodification and marketization from the social studies of markets and finance. But what of capitalization? What is distinctive about this mode of valuation and the reality it impels? What does it mean to live under the ‘asset condition’? In Capitalization: A Cultural Guide, Fabian Muniesa and his colleagues at the Centre de Sociologie de l’Innovation ...

Classification permeates us: our being and our world. This paper seeks to extend the information systems literature on classification by suggesting classification as a quest, involving man, in a process comprised of both finding and producing truth. Drawing on Martin Heidegger’s etymological enquiry, classification is reinterpreted as a dynamic movement towards order. The essence of technology ...

abstract: measles remains one of the leading causes of childhood morbidity and mortality in developing countries and is still a major public health concern in developed countries. although live attenuated vaccine is used throughout the world, out breaks of disease still occur in many countries including iran. understanding measles outbreaks that occur after the initiation of measles elimination...