• Granulation growth literature is reviewed to find solutions for size prediction. Two limiting cases granule are found and equations determined. Growth behaviour also derived by including consolidation behaviour. The prediction matches longstanding regime maps strongly. solution includes nucleation, growth, breakage in a continuous solution. Size control granulation of great importance yet oft...

We trace the Doppler velocity and turbulent velocity elds at diierent heights in the solar overshoot layers using absorption lines of diierent strengths in spec-trograms taken at the center of the solar disk. We show the results for one regular and one exploding granule as two representative examples. The convec-tive velocity patterns do not change with the height up to 200km above 5000 = 1, ne...

Pressure ulcers represent complex wounds that are difficult to prevent or manage. Guidelines for prevention include identifying patients at risk, reducing the effect of pressure, friction, shear forces, and assessing co-morbidities such as nutritional status. Management should follow eight treatment strategies including accurately assessing the ulcer, relieving pressure, assessing pain and nutr...

According to Process Analytical Technology perspective, drug product quality should be ensured by manufacturing process design. Initial step of the process analysis is investigation of critical process parameters (CPPs). It is generally accepted to type the CPPs based on project team knowledge and experience [5]. This paper describes the use of Design of Experiments tool for selection of the CP...

Wet granulation is a key step in the pharmaceutical manufacturing of solid-dosage forms. used production to enhance formulation qualities such as flowability, compressibility, etc. Different methods are for wet granulation, including fluidised bed, twin-screw extrusion, and high-shear method, leading different mechanisms granule properties. Modelling great importance industry, which aspiring sh...

The objective of this study was three-fold; to investigate the different mechanisms of material exchange during the equilibrium phase of the granulation process and whether these mechanisms are consistent with the mechanisms described in the growth regime map, to study how material properties and process conditions affect these exchange mechanisms, and to correlate Stokes deformation number to ...

www.pharmtech.com n the manufacture of many pharmaceutical products, dry-particle blending is a critical step that directly affects content uniformity. Tumbling blenders—a common way to mix granular constituents—are hollow containers attached to a rotating shaft; the vessel is partially loaded with materials and rotated. Their main advantages are large capacities, low-shear stresses, flexibilit...

Micromotion-induced interstitial fluid flow at the bone-implant interface has been proposed to play an important role in aseptic loosening of cementless implants. High fluid velocities are thought to promote aseptic loosening through activation of osteoclasts, shear stress induced control of mesenchymal stem cells differentiation, or transport of molecules. In this study, our objectives were to...