objective the hippocampal circuit integrity is crucial for learning and memory. despite the existing reports on hippocampal–dependent memory impairment due to noise stress, there are only a few studies on the effect of noise stress on anatomical structure of hippocampus. the present study is aimed to investigate the likely effects of chronic noise exposure on the volume of rat hippocampus. mate...

Physiological body temperature is an important determinant for neural functions, and it is well established that changes in temperature have dynamic influences on hippocampal neural activities. However, the detailed molecular mechanisms have never been clarified. Here, we show that hippocampal neurons express functional transient receptor potential vanilloid 4 (TRPV4), one of the thermosensitiv...

Adult-born hippocampal neurons are important for cognitive plasticity in rodents. There is evidence for hippocampal neurogenesis in adult humans, although whether its extent is sufficient to have functional significance has been questioned. We have assessed the generation of hippocampal cells in humans by measuring the concentration of nuclear-bomb-test-derived ¹⁴C in genomic DNA, and we presen...

The hippocampal CA1 region is sensitive to hypoxic and ischemic injury but can be protected by ischemic preconditioning (IPC). However, the mechanism through which IPC protects hippocampal CA1 neurons is still under investigation. Additionally, the role of autophagy in determining the fate of hippocampal neurons is unclear. Here, we examined whether IPC induced autophagy to alleviate hippocampa...

Dense-core granules (DCGs) are organelles found in specialized secretory cells, including neuroendocrine cells and neurons. Neuronal DCGs facilitate many critical processes, including the transport and secretion of proteins involved in learning, and yet their transport and exocytosis are poorly understood. We have used wide-field and total internal reflection fluorescence microscopy, in conjunc...


 Purpose: To study the influence of oxymatrine on hypoxic-ischemic brain injury (HIBI) in neonatal rats.
 Methods: Newborn SPF Sprague-Dawley (SD) rats were randomly assigned to 3 groups (10 rats/group): control, HIBI and groups. Neurobehavioral latency each rat was determined after 48 h treatment, pathological changes cerebral cortex evaluated using H&E staining. Hippocampal neu...

abstractintroduction: previous investigations have shown that protein malnutrition can alters the structure and function of some areas of hippocampal formation. we investigated the effect of protein malnutrition on amygdaloid projections to the ca1 hippocampal area. in this study we investigated level and pattern of distribution of efferent projections from amygdala to hippocampus in the rat by...

Mechanical properties such as force generation are fundamental for neuronal motility, development and regeneration. We used optical tweezers to compare the force exerted by growth cones (GCs) of neurons from the Peripheral Nervous System (PNS), such as Dorsal Root Ganglia (DRG) neurons, and from the Central Nervous System (CNS) such as hippocampal neurons. Developing GCs from dissociated DRG an...

Hippocampal network activity is predominantly coordinated by γ-amino-butyric acid (GABA)ergic neurons. We have previously hypothesized that the altered excitability of hippocampal neurons in Alzheimer's disease (AD), which manifests as increased in vivo susceptibility to seizures in the TgCRND8 mouse model of AD, may be related to disruption of hippocampal GABAergic neurons. In agreement, our p...