the european authors and thinkers in classic period and particularly romantic one were searching the root and basis of european culture and languages. the decoding of sanskrit emphasized the centrality of the orient for european culture. goethe, the famous poet and author of germany, under the influence of this movement and for his own interest, studied the works of orientalists too. alltough h...

selection was amply justified is proved by the wholly admirable work which Dr. Michell Clarke has given us. The phenomena of hysteria have been known and separately recognised in a more or less perfect degree for long past, and good descriptions of the symptom-complex exist in our own and many other languages. The continued evolution of neurology, however, has made more extensive the area of wh...

Significant data to suggest the need for more appropriate precautions for volunteers participating in stage hypnosis is presented. This paper is a case report of a soldier previously injured in battle who, due to participating in stage hypnosis one year after his injury, experienced a dissociative episode wherein post-traumatic stress symptoms were prominent. During this episode, which lasted o...

Starting with my acquaintance with W. Ross Ashby, this paper offers an account of one aspect of his work, information theory. It shows his motivation to embrace information theory, how he extended it, where it failed while fertilizing reconstructability analysis, and what it took for a solution to emerge. Based on Ashby‘s recognition of the material limits of computation, the paper continues hi...

Mussel adhesive proteins have been suggested as a basis for environmentally friendly adhesives for use in aqueous conditions and in medicine. However, attempts to produce functional and economical recombinant mussel adhesive proteins (mainly foot protein type 1) in several systems have failed. Here, the cDNA coding for Mytilus galloprovincialis foot protein type 5 (Mgfp-5) was isolated for the ...

Natural proteins are often confined within their local microenvironments, such as three-dimensional confinement in organelles or two-dimensional confinement in lipid rafts on cytoplasmic membrane. Spatial confinement restricts proteins' entropic freedom, forces their lateral interaction, and induces new properties that the same proteins lack at the soluble state. So far, the phenomenon of envir...

The αvβ6 integrin is up-regulated in cancer and wound healing but it is not generally expressed in healthy adult tissue. There is increasing evidence that it has a role in cancer progression and will be a useful target for antibody-directed cancer therapies. We report a novel recombinant diabody antibody fragment that targets specifically αvβ6 and blocks its function. The diabody was engineered...

We previously expressed VbhTA constructs for lysate AMPylation assays from the pRSFDuet-1 backbone, a plasmid with two multiple cloning sites that each enable the expression of constructs from a PT7 promoter. Our constructs encoded either the VbhT toxin alone (with an N-terminal hexahistidine (His6-)tag) to be expressed from the first multiple cloning site or had additionally the VbhA antitoxin...

In the presence of a low pH environment, the channel-forming T domain of diphtheria toxin undergoes a conformational change that allows for both its own insertion into planar lipid bilayers and the translocation of the toxin's catalytic domain across them. Given that the T domain contributes only three transmembrane segments, and the channel is permeable to ions as large as glucosamine(+) and N...