Fexofenadine hydrochloride (FFH), chemically known as (±)-4-[1-hydroxy-4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]butyl]-a,a-dimethyl benzene aceticacid hydrochloride [1] is a active metabolite of terfenadine and is a second-generation histamine H1-receptor antagonist in piperidine-class drugs. These drugs are used in the treatment of seasonal allergic rhinitis, chronic idiopathic urticaria etc...

conclusions cyclosom and histamine synergistically exert catalepsy in old rats. in light of these data, the combination of the decreased brain level of somatostatin and increased brain level of histamine may be of pathogenic relevance for extrapyramidal signs in pd. results cyclosom (0.2, 1.0, and 5.0 µg) and histamine (1.0 and 10.0 µg) alone were ineffective in both young and old animals. in c...

the effects of some histaminergic agents were evaluated on stress- induced immunosuppression in immunized nale rats. in rat immunized with sheep red blood cells ( srbcs). restraint stress (rs) prevented the booster-induced rise in anti-srbc antibody titre and cell immunity response. intracerebroventicular (i.c>v) injection of histamine (150 µg/rat) induced a similar effect with rs. pretreatment...

To evaluate the ability of histamine to induce ventricular arrhythmias, we studied the effects of histamine on ventricular rhythmicity in the isolated guinea pig heart with complete atrioventricular conduction block. As a function of dose (0.1-30 microgram), histamine enhanced the idioventricular rate by increasing the rate of firing of the original pacemaker and also by causing the sudden appe...

Atypical antipsychotics such as olanzapine and clozapine are effective at treating the multiple domains of schizophrenia, with a low risk of extra-pyramidal side-effects. However a major downfall to their use is metabolic side-effects particularly weight gain/obesity, which occurs by unknown mechanisms. The present paper explores the potential candidature of histaminergic neurotransmission in t...

Myocardial ischemia activates cardiac spinal afferents that transmit the nociceptive information leading to chest pain and elicit excitatory cardiovascular reflexes. Previous studies have shown that histamine is increased in coronary sinus blood during myocardial ischemia and that this autacoid stimulates abdominal visceral afferents. The present investigation evaluated the role of endogenous h...

Drugs with antihistamine action are the most commonly prescribed medication in daily dermatologic practice, both to adults and children. This article addresses new concepts of the role of histamine receptors (H1 receptors) and discusses the anti-inflammatory effects of these drugs. Second generation antihistamines differs from first generation because of their high specificity and affinity for ...

OBJECTIVE Enhanced endothelial permeability leading to intimal accumulation of low-density lipoproteins (LDL) stimulates the formation of atherosclerotic lesions. Histamine is known to increase vascular permeability. Whether this affects the formation of atherosclerotic lesions, however, remains elusive. METHODS AND RESULTS Apolipoprotein E-null (ApoE(-/-)) mice treated with a histamine H1 re...