The copper-containing granules in the mid-gut epithelium of larval Drosophila melanogaster were examined for acid phosphatase by combined histochemistry and energy-dispersive, X-ray microanalysis. After incubation, many of the granules were shown to contain simultaneously copper and sulphur (which are normal constituents), and lead and phosphorus (which are the detectable elements of the reacti...

Oral Absorption and Disposition Kinetics of Lidocaine Hydrochloride in Dogs. R. N. BOYES, H. J. ADAMS AND B. R. DUCE 1 Maternal and Fetal Distribution of H3-Dihydromorphine in the Tolerant and Nontolerant Rat. S. Y. YEH AND L. A. WOODS 9 Retention of Inhaled Acetaldehyde in Man. JOHN L. EGLE, JR 14 Efflux of Chiorpromazine and Trifluoperazine from the Rat Brain. P. F. SPANO, N. H. NEFF, E. MACK...

A technique is described which couples visualization of intracellular horseradish peroxidase (HRP) with histochemical localization of monoamine oxidase (MAO), permitting simultaneous study of histochemistry, morphology and physiology in a single neuron. Using this technique, individual neurons int he tuberomammillary nucleus of the hypothalamus were stained in a Golgi-like fashion, revealing th...

morphology at the macroscopic, microscopic and ultrastructural levels. Wherever appropriate, he goes from structure into function and introduces concepts involving histochemistry, biochemistry, biophysics and bioengineering. The book is easy to read and presents the material in a very concise fashion and focuses upon the need for more extensive microcirculatory research. As an introduction to t...

The effects of maternal diabetes (induced d 78 of gestation) and food deprivation (last 20 d of gestation) on the histochemical disposition of fetal adipose tissue at 112 d of gestation were determined. In both cases, there was an increased number of fat cell clusters by comparison with the control. In the fetuses of diabetic pigs, there were striking effects on adipocyte size and the extent of...

BACKGROUND & OBJECTIVE Matrix metalloproteinases (MMPs) are involved in local invasion of ameloblastomas. This study was to evaluate the role of matrix metalloproteinase inducer (EMMPRIN) in angiogenesis in ameloblastomas by analyzing EMMPRIN expression and microvessel density (MVD) in ameloblastomas and odontogenic cysts. METHODS EMMPRIN expression and MVD in 41 specimens of ameloblastoma an...

Objectives: The present study has tried to analyze the individual and combined expression of the three markers—p53, Ki-67 and bel-2-in HPV associated pre-malignant lesions of the cervix. Methods: Thirty-four cases of high-grade lesions, 21 low-grade cases and 18 normal cases were histologically assessed. HPV-DNA presence and the viral types were determined through PCR and RFLP, respectively. Ma...

For many pathologists, only pedantry can resolve the difference between the terms "histochemistry" and "cytochemistry". Moreover, the better known subject of histochemistry is not distinguished for its quantification. So it may come as some surprise, that the most sensitive bioassays, of polypeptide hormones, that are currently available and that are about one thousand times as sensitive as the...

Selective section of afferent vagal axons that reach below the diaphragm blocks the satiating effect of peripherally administered cholecystokinin in the rat. Section of the analogous efferent axons has no effect. After the behavioral tests, the selective axonal sections were confirmed with horseradish peroxidase histochemistry.

In the mesophyll of Teucrium polium L. leaves, isolated or grouped idioblastic secretory cells occur in contact with the distal (adaxial) vessel elements of the vascular bundles. They appear to originate from one or more bundle sheath cells and their intracellular space is entirely occupied by the secretory material. The latter has a glycoproteinaceous constitution (mucilage), as histochemical ...