Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system that inflammation, demyelination, oligodendrocyte loss, gliosis, axonal injury and neurodegeneration are the main histopathological hallmarks of the disease. Although MS was classically thought as a demyelinating disease, but axonal injury occurs commonly in acute inflammatory lesions. In MS mi...

BACKGROUND Severe burn induces systemic inflammation and reactive oxygen species leading to lipid peroxidation which may play role in remote organs injury. Sildenafil is a selective and potent inhibitor of cyclic guanosine monophosphate specific phosphodiesterase-5. Sildenafil reduces oxidative stress and inflammation in distant organs. The aim of the present study was to evaluate the effects o...

background and objective: smoking can be associated with the decreasing gingival blood flow and epithelial changes. the aim of this study was to evaluate the histopathological changes of gingival epithelium and connective tissue in smokers. methods: the study was case-control. sixty male patients (28 smokers and 32 nonsmokers) suffering chronic periodontitis were participated in the study. peri...

Atopic dermatitis is a chronic relapsing inflammatory common skin disease. It has complex pathophysiology, that involves strong genetic predisposition, epidermal dysfunction, and type 2 inflammation. Kaempferol natural flavonoid widely found in tea, vegetables, fruits. wide range of beneficial pharmacological activities, including excellent anti-oxidation anti-inflammation. However, the therape...

Objective: This investigation aimed to detect the possible protective impacts of naringenin (NAR) on vancomycin (VCM)-induced liver toxicity through measuring caspase-3, -8 and -9 activities as markers apoptosis levels tumor necrosis factor-alpha, cyclooxygenase-2 vascular endothelial growth factor inflammation assessing histopathological alterations in rats. Methods: The rats were allocated in...

We investigated the harmful effects of exposure to a toner with external additives by a long-term inhalation study using rats, examining pulmonary inflammation, oxidative stress, and histopathological changes in the lung. Wistar rats were exposed to a well-dispersed toner (mean of MMAD: 2.1 μm) at three mass concentrations of 1, 4, and 16 mg/m3 for 22.5 months, and the rats were sacrificed afte...

BACKGROUND Porous polyethylene implants are commonly used in orbital blowout fracture repair because of purported biocompatibility, durability, and low frequency of complications. Delayed inflammation related to porous polyethylene sheet implants is very rare and no case series of this condition have been reported. CASE PRESENTATION This is a retrospective review of clinical presentations, ra...

Clinical and histopathological findings in a litter of German Shepherd dogs consisting of seven puppies with acute inflammation confined to the footpads were reported. Affected footpads were characteristically erythematous, swollen and painful. Lesions were present on all four feet in 3/7 cases and on the rear feet in 4/7 cases. None of the dogs had evidence of ectoparasitism. Fecal flotation, ...

OBJECTIVE It is essential to identify a serological marker of injury in order to study the pathophysiology of intestinal ischemia reperfusion. In this work, we studied the evolution of several serological markers after intestinal ischemia reperfusion injury in rats. The markers of non-specific cell damage were aspartate aminotransferase, alanine aminotransaminase, and lactic dehydrogenase, the ...

The objective of this study was to evaluate the usefulness of the laparoscopic technique for performing a biopsy of the gastric and duodenal wall in dogs. Endoscopic examinations were performed in five dogs, which were not conclusively diagnosed based on symptoms and the results of clinical and laboratory tests. A histopathological analysis of laparoscopically collected tissue samples supported...