Apache Flink1 is an open-source system for processing streaming and batch data. Flink is built on the philosophy that many classes of data processing applications, including real-time analytics, continuous data pipelines, historic data processing (batch), and iterative algorithms (machine learning, graph analysis) can be expressed and executed as pipelined fault-tolerant dataflows. In this pape...

and Chromatin Dynamics was one of the largest Keystone meetings to date, reflecting the excitement and many developments in this area. Richard Young opened the meeting by giving a historic overview before sharing more detailed insights from his recent work in describing the role of the lysine demethylase Lsd1 in mouse embryonic stem (ES) cell differentiation. He also set the broader stage and h...

Understanding extinction drivers in a human-dominated world is necessary to preserve biodiversity. We provide an overview of Quaternary extinctions and compare mammalian extinction events on continents and islands after human arrival in system-specific prehistoric and historic contexts. We highlight the role of body size and life-history traits in these extinctions. We find a significant size-b...

Abstract We introduce a notion of sensitivity with respect to continuous real-valued bounded map which provides sufficient condition for transformation, acting on Baire metric space, exhibit generic subset points historic behavior (also known as irregular points). The applications this criterion recover, and extend, several theorems the genericity set, in addition yielding number new results, i...

the historic environment is an irreplaceable asset representing the investment of centuries of skills and resources. it gives places a unique competitive advantage. most of it is in daily use; it is capable of an economic future. the opportunities for regenerating historic environment require both conservation and development motivators to keep a unique sense of the historic environment whilst ...

Reconstruction and arthrodesis play a dominant role in the surgical treatment of various disorders of the hindfoot. Subtalar joint (STJ) arthrodesis has accomplished favorable results in the treatment of various disorders such as primary and secondary osteoarthritis, rheumatoid arthritis, neuromuscular disorders, congenital deformity, and adult hindfoot pathology. Likewise, STJ fusion provides ...

The goal of my article was not to review the Camp Lejeune (CLJ) modeling studies. Rather it was to use the CLJ problem as an example to highlight issues related to model complexities and to spark an open debate on when, where, and why we should limit model complexity. I would like to first thank Maslia and his nine co-authors for contributing to this debate. I believe this is an important debat...

background and objectives: in the last few decades, losses of our cultural heritage due to biodeteriorationare beinghighly recognized. from museum objects to rock monuments, the microbial biodeterioration agents are found to be the most destructive. possibilities for proper preservative measure(s) are always more when it is only a monument, statue, museum article, or pre-historic art in any sma...