Therapeutics against breast cancer is a major research field, due to inefficiency or partial efficiency of existing therapeutics. An urge discover better therapeutics always persists. Our objective study salicin cells, in order find its therapeutic properties. To the effect on we performed MTT assay MCF-7 (hormone positive) and MDA-MB-231 (triple negative) cell lines, did brine shrimp lethality...

The ovarian steroid hormones have numerous effects on the brain, many of which are mediated, at least in part, by interaction with intracellular steroid hormone receptors acting as regulators of transcription. These intracellular steroid hormone receptors have often been considered to be activated solely by cognate hormone. However, during the past decade, numerous studies have shown that the r...

Receptors for peptide hormones and neurotransmitters are integral components of the plasma membrane of cells which serve to couple the external milieu to the intracellular regulators of metabolism. These macromolecules are usually high molecular weight glycoproteins, and in many cases appear to have more than one subunit capable of binding the hormone. The interaction of the hormone or neurotra...

Thyroid hormone is essential for normal development, differentiation, and metabolic balance. Thyroid hormone action is mediated by multiple thyroid hormone receptor isoforms derived from two distinct genes. The thyroid hormone receptors belong to a nuclear receptor superfamily that also includes receptors for other small lipophilic hormones. Thyroid hormone receptors function by binding to spec...

Small-molecule plant hormones principally control growth, development, differentiation, and environmental responses. Nine types of are ubiquitous in angiosperms, the molecular mechanisms their hormone actions have been elucidated during last two decades by genomic decoding model plants with genetic mutants. In particular, discovery receptors has greatly contributed to understanding signal trans...

The mechanisms regulating cortisol production when ACTH of pituitary origin is suppressed in primary adrenal causes of Cushing's syndrome (CS) include diverse genetic and molecular mechanisms. These can lead either to constitutive activation of the cAMP system and steroidogenesis or to its regulation exerted by the aberrant adrenal expression of several hormone receptors, particularly G-protein...