We monitored the spatial distribution of exo- and endocytosis at 37 degrees C in mouse motor nerve terminals expressing synaptopHluorin (spH), confirming and extending earlier work at room temperature, which had revealed fluorescent 'hot spots' appearing in repeatable locations during tetanic stimulation. We also tested whether hot spots appeared during mild stimulation. Averaged responses from...

BACKGROUND/AIMS Achalasia patients would feel exacerbated dysphagia, chest pain and regurgitation when they drink cold beverages or eat cold food. But these symptoms would relieve when they drink hot water. Reasons are unknown. METHODS Twelve achalasia patients (mean age, 34 ± 10 years; F:M, 3:9) who never had any invasive therapies were chosen from Peking Union Medical College Hospital. They...

For the past eight years the Globe and Mail newspaper has held an annual stock picking contest entitled My One and Only. In this competition, which starts on January 1 of each year, a variety of financial commentators, money managers and even academics are asked to select one stock – from the universe of stocks trading above $1 – of any public company quoted on the Toronto Stock Exchange (TSE)....

one of the most important advantages of particle simulation as compared to fluid simulation is the capacity for working with and tracing particles. in particle simulations, the test particle method is usually used to get some idea of the behavior of plasma or other substances. in this method, first, a small number of particles are injected into the frame of static electromagnetic fields. then, ...

This paper reports an ethnography of ambulance dispatch work in a large UK metropolitan region. The interplay between control centre ecology, usage of a computerised dispatch system, and cooperative work of control personnel is analysed. The methods by which a 'working division of labour' is sustained to effectively manage dispatch in the face of high workload and manifold contingency are expli...

Hot and cold water, in comparison to room temperature water, ingested by normal young men, profoundly alters esophageal motor function. Cold water slows or abolishes esophageal peristalsis, prolongs the contraction wave in the distal esophagus, produces a delayed but prolonged relaxation of the lower esophageal sphincter, and regularly causes a lower esophageal sphincteric contraction of increa...