A 69-year-old female with a history of breast cancer and hypertension presented with a rare case of herpes simplex encephalitis (HSE) isolated to her left parietal lobe. The patient's first biopsy was negative for herpes simplex virus (HSV) I/II antigens, but less than two weeks later, the patient tested positive on repeat biopsy. This initial failure to detect the virus and the similarities be...

Fieldbus Foundation's open, integrated architecture for information integration consists of a field-level bus, a host-level network based on Ethernet, and at a higher level ties in with OPC for data server integration. These three technologies complement each other rather than compete. They have several mutually exclusive features making them suitable for different functions, together resulting...

The c-myb proto-oncogene product (c-Myb) can transactivate the human hsp70 promoter in a transient cotransfection assay. The present studies have demonstrated that the heat shock element (HSE) in the hsp70 promoter mediates trans-activation by c-Myb. Mutagenesis of the DNA sequence in HSE indicated that the NGAAN motif is necessary for not only the heat shock response but also the c-Myb-induced...

The factors which cause herpes simplex encephalitis (HSE) to occur among herpes simplex virus type 1 (HSV-1) infected humans are not understood. In experimental models, HSV-1 neuroinvasiveness is influenced by amino acid changes in HSV glycoproteins D (gD) or B (gB), which are essential to the virus infectivity and to the induction of host immune responses. To test the possible involvement of t...

L O’Connor ([email protected])1, M Ward1, D Bennett2, R Mulhall2, P O’Lorcain3, R Cunney2,3, R McDermott1, E Neville4, J Heslin4, R FitzGerald5, K Meyler2, M Conlon1, A Clarke1, B Corcoran6, G Fitzpatrick1, B O’Connor4, P Flanagan3, D O’Flanagan3, S Cotter3 1. Department of Public Health, HSE East, Dr Steevens’ Hospital, Dublin, Ireland 2. Epidemiology and Molecular Biology Unit, Temple ...