OBJECTIVE Avoiding abacavir in HIV-infected patients tested positive for HLA-B*5701 reduces the risk of abacavir hypersensitivity reaction (ABC-HSR). Our aim was to assess the costs of clinically suspected HSR and to estimate potential cost savings of implementing prospective HLA-B*5701-screening for HIV-infected patients initiating abacavir/lamivudine fixed-dose combination (ABC/3TC FDC) compa...

As more countries witness depopulation, the expansion of High-Speed Rail (HSR) to reach shrinking cities in peripheral regions is renewing debate on effects this infrastructure. This case Japan, a country that continues extend its highly developed HSR network hoping curb regional decline. paper investigates whether had positive effect trajectories connected medium and small-sized by examining i...

This paper describes the implementation of the Portuguese High Speed Rail (HSR) Network. The business model developed by RAVE for the PPP's related with the HSR infrastructure is described and discussed. Following a recently awarded research project (EXPRESS) aimed at studying the strategic aspects related with the implementation of HSR is presented and its aspects more directly related with HS...

The heat shock response (HSR) is an evolutionarily conserved molecular/biochemical reaction to thermal stress that is essential to the survival of eukaryotic organisms. Recessive Mutator transposon mutations at the maize empty pericarp2 (emp2) locus led to dramatically increased expression of heat shock genes, retarded embryo development, and early-stage abortion of embryogenesis. The developme...

The heat shock response (HSR) is a highly conserved protective mechanism that enables cells to withstand diverse environmental stressors that disrupt protein homeostasis (proteostasis) and promote protein misfolding. It has been suggested that small-molecule drugs that elicit the HSR by activating the transcription factor heat shock factor 1 might help mitigate protein misfolding and aggregatio...

In April 2009 the US government unveiled its blueprint for a national network of high-speed passenger rail (HSR) lines aimed at reducing traffic congestion, cutting national dependence on foreign oil and improving rural and urban environments. In implementing such a program, it is essential to identify the factors that might influence decision making and the eventual success of the HSR project,...

INTRODUCTION Approximately 4% to 8% of patients with HIV-1 treated with abacavir present a hypersensitivity reaction (HSR). Various studies have shown a direct association between human leukocyte antigen (HLA)-B*5701 and HSR to abacavir. The objective of this study was to analyze whether systematic HLA-B*5701 testing to prevent HSR in patients treated with abacavir is a cost-effective option fo...

Correspondence to: Thomas M. Maddox, MD, MSc, Cardiology Section 111B, VA Eastern Colorado Health Care System, 1055 Clermont St, Denver, CO 80210. E-mail thomas.maddox@ va.gov Thomas M. Maddox, MD, MSc P. Michael Ho, MD, PhD H ealth services research (HSR) is a multidisciplinary field of scientific inquiry that examines how people access health care, how that care is delivered, how much it cost...

In a 2006 article in Alternative Therapies in Health and Medicine, Herman et al argued cogently that adopting a health services research (HSR) paradigm would help resolve some of the issues that the complementary and alternative medicine (CAM) community and those researching CAM face with randomized controlled trials. Although the article makes a strong case for HSR and CAM, it fails to discuss...