Many pharmacogenomic biomarkers (PGBM) were identified and translated into clinical practice, affecting the usage of drugs via label updates. In this context, abacavir is one of the most brilliant examples of pharmacogenetic studies translated into clinical practice. Pharmacogenetic studies have revealed that abacavir HSRs are highly associated with the major histocompatibility complex class I....

Background Anifrolumab, a human monoclonal antibody (mAb), is approved in Canada, Japan, and the United States for treatment of patients with systemic lupus erythematosus (SLE) based on results from phase 2b MUSE 3 TULIP-1/-2 trials. 1–3 Anaphylactic reactions (ARs), hypersensitivity (HSRs), infusion-related (IRRs) are risks mAb infusions, so physicians prescribing anifrolumab may wish to under...

BACKGROUND Recommendations that nevirapine (NVP) should be avoided in female individuals with CD4 cell counts >250 cells/microL and in male individuals with CD4 cell counts >400 cells/microL are based on findings in treatment-naive patients. It is unclear whether these guidelines also apply to treatment-experienced patients switching to NVP-based combination therapy. METHODS Patients in the A...

“Furthermore, a Cmax analysis showed that the oral administration of HSRW resulted in a high hydrogen concentration (more than 300 ppb/g) in the tissues of the spleen, small intestine and pancreas (Fig. 4A). Meanwhile, the intraperitoneal administration of HSRS resulted in a high hydrogen concentration in the spleen and pancreas (more than 300 ppb/g) (Fig. 4B). However, the hydrogen concentrati...

Fire parameter estimation is performed using data obtained quasi-simultaneously by the Hot Spot Recognition System (HSRS) on the experimental Bi-spectral InfraRed Detection (BIRD) satellite and the MODerate resolution Imaging Spectro-radiometer (MODIS) on EOS Terra. Compared with the higher spatial resolution BIRD data, MODIS can not detect small fires, which leads in some cases to an underesti...

BACKGROUND Although drug-induced peripheral eosinophilia complicates antimicrobial therapy, little is known about its frequency and implications. OBJECTIVE We aimed to determine the frequency and predictors of antibiotic-induced eosinophilia and subsequent hypersensitivity reactions (HSRs). METHODS We evaluated a prospective cohort of former inpatients receiving intravenous antibiotic thera...

Abstract Background The optimal treatment for recurrent high-grade gliomas (rHGGs) remains uncertain. This study aimed to investigate the efficacy and safety of hypofractionated stereotactic radiosurgery (HSRS) as a first-line salvage in-field recurrence gliomas. Methods Between January 2016 October 2019, 70 patients with rHGG who underwent HSRS were retrospectively analysed. primary endpoint w...

BACKGROUND The rising cost of healthcare is of great concern in China, as evidenced by the media features negative reports almost daily. However there are only a few studies from well-developed cities, like Beijing or Shanghai, and little is known about healthcare costs in rest of the country. In this study, we use hospitalization summary reports (HSRs) from admitted cardiovascular diseases pat...

Biologics encompass a class of new therapeutic agents that consists mAbs, fusion proteins, and nanobodies. Adverse reactions to biologics limit their use have broad clinical impact because they affect all medical specialties.1Isabwe G.A.C. Garcia Neuer M. de las Vecillas Sanchez L. Lynch D.M. Marquis K. Castells Hypersensitivity monoclonal antibodies: phenotypes endotypes.J Allergy Clin Immunol...