Some unidentified RNA molecules, together with the nucleoid protein HU, were suggested to be involved in the nucleoid structure of Escherichia coli. HU is a conserved protein known for its role in binding to DNA and maintaining negative supercoils in the latter. HU also binds to a few RNAs, but the full spectrum of its binding targets in the cell is not known. To understand any interaction of H...

The nucleoid-associated protein HU is one of the most abundant proteins in Escherichia coli and has been suggested to play an important role in bacterial nucleoid organization and regulation. Although the regulatory aspects of HU have been firmly established, much less is understood about the role of HU in shaping the bacterial nucleoid. In both functions (local) modulation of DNA architecture ...

Introduction: Pixel value in computed tomography (CT) gives the average linear attenuation coefficient of the scanned material in the path of the x-ray beam, being normalized to that of water. It is known that attenuation coefficient or HU value is a function of the chemical characteristic of the material and of the x-ray energy. The CT image shows the HU value by a shade of gr...

BACKGROUND Patients with neuroendocrine-related tumors and paraneoplastic encephalomyelitis (PEM) or paraneoplastic sensory neuronopathy (PSN) develop high titers of antibodies, called anti-Hu, against neuronal proteins expressed in their tumors, usually small cell lung cancer (SCLC). These tumors appear to be more indolent than those not associated with anti-Hu antibodies. The aims of this stu...

The goal of this study was to determine the effects of microgravity on myofilament protein expression and both passive and active length-force relationships in carotid and femoral arteries. Microgravity was simulated by 20-day hindlimb unweighting (HU) in Wistar male rats, and carotid and femoral artery segments were isolated from both HU and control (CTL) rats for Western blot and length-force...

OBJECTIVE To evaluate progressive enhancement in the carotid arterial wall overlying plaque in the symptomatic side for patients with cerebrovascular symptoms until delayed phase using MDCTA. MATERIALS AND METHODS Twenty-one patients (all men; ages, 49-82 years; mean, 67.8 ± 8.4 years) with recent stroke and severe extracranial carotid stenosis were retrospectively analyzed. Pre-, early- and ...

Hydroxyurea (HU) is commonly used to treat myeloproliferative diseases and sickle cell anemia. The administration of HU to gestation day 9 CD1 mice causes predominantly hindlimb, tail, and neural tube defects. HU induces oxidative stress and p38 mitogen-activated protein kinase (MAPK) signaling in embryos. HU also inactivates ribonucleotide reductase, leading to DNA replication stress and DNA d...

Introduction: Cortical thickness, interradicular space width and bone density are key factors in the use of mini-implants as anchorage. Objective: This study assessed maxillary and mandibular alveolar and basal bone density in Hounsfield units (HU). Method: Eleven files with CT images of adults were used to obtain 660 measurements of bone density: alveolar (buccal and lingual cortical) bone, ca...

[∗] Dr. B. Hu , Y. Ding , D. Kulkarni , Y. Shen , Prof. V. V. Tsukruk , Prof. Z. L. Wang School of Materials Science and Engineering Georgia Institute of Technology Atlanta, GA 30332-0245 (USA) E-mail: [email protected] Dr. B. Hu , Prof. W. Chen State Key Laboratory of Advanced Technology for Materials Synthesis and Processing School of Materials Science and Engineering Wuhan University...

Unloading-induced muscle atrophy occurs in the aging population, bed-ridden patients, and astronauts. This study was designed to determine whether dynamic foot stimulation (DFS) applied to the plantar surface of the rat foot can serve as a countermeasure to soleus muscle atrophy normally observed in hindlimb unloaded (HU) rats. Forty-four mature (6 mo old), male Wistar rats were randomly assign...