BACKGROUND Studies from various countries have found an increasing incidence of childhood leukemia in recent decades. To characterize time trends in the age- and sex-specific incidence of childhood acute leukemia during the last 20 years in the Nordic countries, we analyzed a large set of population-based data from the Nordic Society of Paediatric Haematology and Oncology (NOPHO) in their acute...

Evaluation the Effect of Chemotherapy Drugs and Thiosemicarbazone Complexes on Expression URHC CASC15 LncRNAs in Acute Lymphoblastic Leukemia Cell Line

acute lymphoblastic leukemia is the most common form of pediatric cancer which is categorized into three l1, l2, and l3 and could bedetected through screening of blood and bone marrow smears by pathologists. due to being time‑consuming and tediousness of theprocedure, a computer‑based system is acquired for convenient detection of acute lymphoblastic leukemia. microscopic images areacquired fro...

Lymphocyte-dependent antibodies (LDA's) directed against antigenic determinants present on lymphoblastoid cell lines as well as human leukemia blast cells were demonstrated in heterologous antisera obtained by immunizing rabbits with a membrane fraction from RPMI-4265 (a lymphoblastoid cell line derived from a patient with chronic myelogenous leukemia). LDA was present at high titers against B-...

introduction: despite achievements in treating acute lymphoblastic leukemia (all) in children, its burden on the psychosocial status of patients is not well defined yet. this study aims to determine the impact of childhood all on emotional and behavioral pattern of the patients compared to healthy peers as assessed by the child behavior checklist (cbcl). methods: we studied 100 children with al...

FMS-like tyrosine kinase-3 is a receptor tyrosine kinase expressed by immature hematopoietic cells and is important for the normal development of stem cells and the immune system. Mutations of FMS-like tyrosine kinase-3 have been detected in about 30% of patients with acute myelogenous leukemia and a small number of patients with acute lymphoblastic leukemia. The FMS-like tyrosine kinase-3 muta...

Oncoprotein E2a/Pbx1 is produced by the t(1;19) chromosomal translocation of human pre-B acute lymphoblastic leukemia. E2a/Pbx1 blocks differentiation of primary myeloid progenitors but, paradoxically, induces apoptosis in established pre-B-cell lines, and no transforming function of E2a/Pbx1 has been reported in cultured lymphoid progenitors. Here, we demonstrate that E2a/Pbx1 induces immortal...

The appendix is an unusual site for extramedulary relapse in acute leukemia. The present case report describes two cases of late course acute lymphoblastic leukemia presented with leukemic infiltration of the appendix and complete remission of bone marrow. The signs and symptoms of the cases suggest that leukemic involvement of the appendix should be considered in the differential diagnosis of ...