conclusions the results of this study showed that the meticulous microsurgical nerve repair, which was performed using the vein tubulization induced significantly better sciatic nerve regeneration. however, the addition of bone marrow mesenchymal stem cell to vein conduit failed to promote any significant changes in regeneration outcome. results all animals tolerated the surgical procedures and...

objective(s): bone marrow-derived mesenchymal stem cells (bm-mscs) potentials make them appropriate for cell therapy including ability of differentiation and release of anti-inflammatory cytokines and growth factors secreta. for treatment of azoospermia to induce proliferation and differentiation of germ cells, mscs transplantation has been introduced. the aim of the present experimental case-c...

objective: evaluating the effects of p-benzoquinone and hydroquinone on the runx2 expression and osteoblastic differentiation of human marrow derived mesenchymal stem cells (mscs). materials and methods: bone marrow mscs obtained by cultivating marrow mononuclear cells, were exposed to 10μm of either p-benzoquinone or hydroquinone. following chemical treatment, runx2 gene expression was assess...

background: bone marrow and umbilical cord stromal cells are multipotential stem cells that have the ability to produce growth factors that play an important role in survival and generation of axons. the goal of this study was to evaluate the effects of the two different mesenchymal stem cells on peripheral nerve regeneration. materials and methods: in this experimental study, a 10 mm segment o...

objective(s)tissue engineering is an attractive science because it promises new therapeutic strategies for repairing organs that have lost functions due to damage. the purpose of this study was to evaluate induction effect of human gingival scaffold in tissue engineering for skin regeneration.materials and methodstissue samples were obtained from crown-lengthening procedures and wisdom teeth re...

Comment on: Jiang et al. Gene expression profiling suggests a pathological role of human bone marrow-derived mesenchymal stem cells in aging-related skeletal diseases. Aging 2011; this issue. In this issue of Impact Aging, Jiang et al. report key differences in the patterns of expressed mRNAs in bone-marrow mesenchymal stem cells (bmMSCs) of young donors compared with old human donors.

bone tissue engineering has been one of the most promising areas of research, providing a potential clinical application to cure bone defects. recently, various stem cells, including embryonic stem cells (escs), bone marrow-derived mesenchymal stem cells (bm-mscs), umbilical cord blood-derived mesenchymal stem cells (ucb-mscs), adipose tissue-derived stem cells (adscs), muscle-derived stem cell...

background bone marrow and adipose tissue are two main sources of mesenchymal stem cells (mscs). some of studies suggest that there are some differences in gene expression profile of mscs-derived from various tissues. to investigate gene expression profile by qrt-pcr, an appropriate reference gene with stable expression level should be chosen for normalizing data.  this study was designed to ev...

objective(s):sea cucumber derived bioactive compound is considered efficient in treatment of bone disorders. this study was performed   to evaluate the effect of this extract on differentiation of rat bone marrow mesenchymal stem cells (rbmmsc) into osteogenic lineage. materials and methods: isolated rbmmsc were grown in dmem supplemented with 10% fbs. the cells were exposed to different concen...