The study of animal retroviruses has yielded fundamental insight into molecular pathways of carcinogenesis, while human retroviruses predispose infected persons to develop malignant disease. Human T-cell lymphotropic virus type I (HTLV-I) causes adult Tcell leukaemia. Human immunodeficiency virus types 1 and 2 (HIV-1, HIV-2) indirectly cause lymphoma, Kaposi’s sarcoma and cervical carcinoma by ...

Adult T-cell leukemia-lymphoma (ATL), a rare and aggressive T-cell malignancy caused by human T-cell lymphotropic virus type 1 (HTLV-1), is associated with a poor prognosis. Evidence-based standard treatment options are lacking and outcomes are generally unsatisfactory, particularly for patients with relapsed or refractory disease. Continued research is contributing to changing treatment landsc...

Adult T-cell leukemia/lymphoma (ATLL) is an aggressive type of non-Hodgkin's lymphoma that can be primary the skin or secondary, caused by Human lymphotropic virus (HTLV-1) infection. The prevalence HTLV-1 infection high in Brazil, however reports ATLL are rare, possibly underdiagnosed and underreported. This paper presents a case report patient coming from south region country with few cited c...

Abstract Adult T-cell leukemia/lymphoma (ATL) is a highly aggressive malignancy that arises in proportion of individuals who are long-term carriers human T-lymphotropic virus type 1. The median survival subtypes 8 to 10 months; with chemotherapy-based approaches, overall has remained largely unchanged the ?35 years since ATL was first described. Through use 4 representative case studies, we hig...

We reported two cases of patients with coinfection by human immunodeficiency virus (HIV) type 1 and human T-cell lymphotropic virus (HTLV) type I who developed opportunistic infections despite of relatively high CD4+ cells count. These cases showed clinical evidence to consider an earlier antiretroviral treatment for coinfected patientes regardless CD4+ cells counts.

Reported at the beginning of the 1980s, Human T lymphotropic viruses type 1 and 2 (HTLV1, HTLV 2) were the first retroviruses to have been detected in human beings. HTLV 1 was isolated from adult T-cell leukemia (ATL) and first described by Takatsuki et al. in Japan in 1976, as a malignancy that only affects T cells and only in adults (1, 2). Albeit infrequent, HTLV-1 infection may lead to seve...