Tobacco harm reduction—encouraging the use of cigarette alternatives as a way to reduce the public health impact of smoking—is the subject of fierce debate in the public health community. Some believe such alternatives perpetuate nicotine addiction in smokers and may even be manufactured and marketed specifically to keep smokers smoking. “The goal should be relief from addiction to nicotine, no...

•Chronic vaping disrupts the gut barrier and triggers inflammation•Transcriptome studies reveal broad impact of e-cig on health•Enteroid monolayers that e-liquid, not nicotine, is culprit•Chronic exposure to increases susceptibility bacterial infection E-cigarette usage continues rise, yet safety e-cigarette aerosols questioned. Using murine models acute chronic aerosol inhalation, colon transc...