Hydatidiform mole (H. mole), a gestational trophoblastic disease, is common in the Philippines. In general, differentiation between complete hydatidiform and partial based on morphologic evaluation via routine H&E. The problem lies lack of standard criteria overlapping features. p57kip2 immunohistochemical stain inexpensive, locally available, could provide reliable results differentiating ...

with a normal fetus and placenta. Twin pregnancies with partial hydatidiform mole coexisting with a live fetus are rarely reported, since fetuses identified with partial mole are generally triploid and tend to die in the first trimester.1,3,4 Hydatidiform mole with live fetus is associated with the risk of many maternal and fetal complications such as vaginal bleeding, preeclampsia, thromboembo...

AIMS To develop an assay which would determine the parentage of hydatidiform molar pregnancies. METHODS DNA was extracted from formalin fixed, paraffin wax embedded tissue from hydatidiform molar pregnancies and spontaneous abortions after separation of chorionic villi and decidua. PCR amplification of dinucleotide repeat sequences ("microsatellites") was performed using three different prime...

Normal trophoblast of the human placenta elaborates at least two major protein hormones, chorionic gonadotropin (hCG), and placental lactogen (hPL). There are several gestational trophoblastic diseases of the placenta called hydatidiform mole, invasive mole, and choriocarcinoma. Molar and choriocarcinoma tissues characteristically synthesize large amounts of hCG and small quantities of hPL. To ...

In spite of the widespread use of assisted reproductive technology, there have been, to our knowledge, only two reported cases of molar pregnancies after gamete intra-Fallopian transfer and five reported cases after in-vitro fertilization and embryo transfer. We report here a case of a complete hydatidiform mole in a twin pregnancy after gamete intra-Fallopian transfer, as well as a case of a c...

Twin molar pregnancy with a hydatidiform mole and a coexisting live fetus is a rare form of gestational trophoblastic disease associated with an increased risk of obstetric complications and poor perinatal outcome. Prenatal diagnosis is essential for couple counseling and follow-up in Tertiary Reference Centers. Magnetic resonance imaging is important for the diagnostic differentiation of place...

A dichorionic twin pregnancy with complete hydatidiform mole and coexistent fetus is a rare and challenging situation, whose pathogenesis has not been yet fully understood. We present a case of a 39-year-old woman who underwent intracytoplasmic sperm injection with two embryos transfer. The 12-week gestation ultrasound examination revealed normal fetus and placenta with features of hydatidiform...