Cinnamon (Cinnamomum burmannii) leaves extract contains secondary metabolites such as flavonoids, saponins, tannins, alakloids, steroids/terpenoids and phenols. The aims of this study was to examine the anti-inflammatory activity ethanolic cinnamon topically determine best concentration for treatment inflammation. This research is an experimental with a post test only control group design appro...

That the properties of adrenal cortical hormones may be modified by relatively minor alterations in their structural formulae is well known. Addition or removal of various chemical radicals and groupings at one or another carbon position in the steroid nucleus may enhance or lessen one or more of the physiological activities of the parent compound. The imagination of chemists has been so stimul...

Peripheral blood mononuclear cells (PBMC) were isolated from seven normal subjects, eight asthmatic subjects clinically sensitive to corticosteroids (CS), and eight asthmatic subjects clinically resistant to corticosteroids (CR). PBMC were cultured at 37 degrees C for 24 h in the absence or presence of 10(-16) to 10(-4) M hydrocortisone. Calcium ionophore (A23187)-activated neutrophils (PMN) pr...

Corticosteroids suppress the humoral antibody response of mice to sheep erythrocytes. This response depends on interactions between thymus-derived helper cells and bone marrow-derived antibody-forming cell precursors (AFC precursors). Previous experiments had shown that spleen cells (a mixture of thymus-derived and marrow-derived cells) were sensitive to corticosteroids while AFC precursors in ...

Hydrocortisone acetate (HA) is a synthetic corticosteroid and is usually employed in the treatment of classic congenital adrenal hyperplasia (CAH), which is a disorder of the adrenal cortex characterized by cortisol deficiency, with or without aldosterone deficiency, and androgen excess [1]. Because five enzymatic steps are involved in cortisol biosynthesis, there are five distinct CAH syndrome...

A minced liver system from Rana catesbeiana tadpoles has been developed. Treatment of this liver preparation in vitro with insulin results in the activation of glycogen synthetase. Hormonally induced activation is the result of the conversion of the less active form of the enzyme to the more active form. The insulin-mediated activation is counteracted by hydrocortisone and dibutyryl-cyclic aden...