Metoprolol succinate (M.succinate), a BCS Class I drug is the most widely prescribed anti-hypertensive drug and is considered to be safe. Owing to its high solubility, fabrication of an extended release matrix formulation becomes extremely challenging. Hydrophilic matrix polymers are the preferred systems for developing an extended release formulation. However, for highly soluble drugs, it fail...

A hydrophilic matrix tablet is the simplest and most cost-effective method of fabricating an extended release (ER) solid oral dosage form. The majority of commercially available matrix formulations are in the form of tablets, and their method of manufacture is similar to conventional tablet formulations: granulation, blending, compression and coating. In its simplest form, a typical ER matrix f...

purpose : to report clinical and pathological features of three cases of opacification with hydrophilic acrylic intraocular lenses (iols) case reports : in this interventional case report, we introduce the surgical and laboratory information about three hydrophilic acrylic iols which calcified after implantation for these patients with cataract. these lenses were explanted and analyzed with opt...

The stochastic nature of single-molecule charge transport measurements requires collection of large data sets to capture the full complexity of a molecular system. Data analysis is then guided by certain expectations, for example, a plateau feature in the tunnelling current distance trace, and the molecular conductance extracted from suitable histogram analysis. However, differences in molecula...

The current study involves development of oral bioadhesive hydrophilic matrices of hydralazine hydrochloride, and optimization of their in vitro drug release profile and ex vivo bioadhesion against porcine gastric mucosa. A 32 central composite design was employed to systematically optimize the drug delivery formulations containing two polymers, viz., carbomer and hydroxypropyl methyl cellulose...

INTRODUCTION Hydrophilic matrices represent a popular and widely used approach for oral extended release (ER) drug delivery. Hypromellose (HPMC) remains the polymer of choice as the release rate-controlling component. In addition to HPMC, polyethylene oxide (PEO) has been extensively studied as a matrix-forming polymer. This is mainly attributed to its availability in a range of molecular weigh...