The metabolism of 7-ethyl- and 7-propyl-chenodeoxycholic acids was studied in hamsters. Both bile acid analogs were absorbed efficiently by the intestine and secreted into the bile at rates similar to those of chenodeoxycholic acid. After intraduodenal administration into bile fistula hamsters, the 7-alkyl analogs were present in bile as the glycine and taurine conjugates. The glycine/taurine r...

TiO2 photo catalyst was prepared in presence of nano SiO2 and Hydroxy Propyl Cellulose (HPC) by sol gel method with Titanium Tetra IsoproPoxide (TTIP) as titanium precursor. Additional effect of HPC in preparation of nano catalyst, and photo catalyst properties measured and characterized by FT-IR, FT-Raman and SEM. The catalyst size and structural properties of the film were determined by .-Ray...

      The objective of the present study was to develop floating microspheres of cefpodoxime proxetil in order to achieve an extended retention in the upper GIT, which may result in enhanced absorption and thereby improved bioavailability. The microspheres were prepared by non-aqueous solvent evaporation method using polymers such as hydroxyl propyl methyl cellulose (HPMC K 15 M), ethyl cellulo...

The Common Cold remains the most frequent symptomatic viral infection in man. Current best therapies are all symptomatic. New pharmacological therapies are likely to be prescription-bound, and as most Common Cold infections are successfully treated without the intervention of a Physician, there is a need for effective non-prescription therapy options. Aim of this study is to propose a new type ...

Abstract The main aim of this study was to prepare and evaluate the extended - release system of an anxiolytic substance. Alprazolam is a short-acting benzodiazepine with general properties similar to those of diazepam. Our studies focused on the development of extended drug delivery system based on Hydroxy Propyl Methyl Cellulose (HPMC 4000cps) as retard agent and polyvinylpyrrolidone (PVP k30...

the objective of the present study was to develop floating microspheres of cefpodoxime proxetil in order to achieve an extended retention in the upper git, which may result in enhanced absorption and thereby improved bioavailability. the microspheres were prepared by non-aqueous solvent evaporation method using polymers such as hydroxyl propyl methyl cellulose (hpmc k 15 m), ethyl cellulose in ...

Using time resolved ESR spectroscopy and photoflash conductivity the uncatalysed, first order decay of 2-hydroxy-propyl-2-peroxyl radicals and the uncatalysed, first order generation of 0 2~ and H + were measured to have the same rate constants. The formation of 0 2~ and H+ was measured in H20 and D 20 and a kinetic isotope effect of kH/k = D3.5 was obtained. Comparing the rate constants of the...