The purpose of present investigation was to develop and optimize bucco mucoadhesive bilayered tablets of Propranolol hydrochloride (PrHCL) using the bioadhesive polymers hydroxyl propyl methyl cellulose (HPMC K4M), xanthan gum (XG) and acrypol 934P (AL-P) individually and in combination along with ethyl cellulose (EC) as an impermeable backing layer. The 3 full factorial design was employed by ...

The objective of the present study was to develop ofloxacin medicated dental gels for extended period of time. The clinical evaluation of ofloxacin was carried out to determine the efficacy in the treatment of periodontitis. The ofloxacin medicated dental gels prepared with different hydrophilic polymers methyl cellulose, hydroxy propyl methyl cellulose, hydroxy propyl cellulose and hydroxy eth...

The aim of the present research was to develop a bilayer tablet of venlafaxine hydrochloride for bimodal drug release. In the present investigation authors have tried to explore fenugreek mucilage (FNM) for bioadhesive sustained release layer. The attempt has been made to combine FNM with well studied bioadhesive polymers like hydroxy propyl methyl cellulose (HPMC), Carbopol, and Xanthan Gum. T...

A study has been carried out to assess the potential use of pectin in combination with two added hydrocolloids, i.e., hydroxy-propyl-methyl cellulose and hydroxyethyl cellulose in varied concentrations and coated with ethyl cellulose and cellulose acetate phthalate. The results of in vitro drug release showed that the matrix tablets prepared with pectin, hydroxy ethyl cellulose (20 percent) whe...

The present work reports on the use of a hybrid blend biopolymers as matrix for lipase immobilization. (Hydroxypropyl)methyl cellulose (HPMC) and Chitosan (CS) were combined in order to formulate film which Mucor miehei was immobilized. biocatalyst studied upon model reaction propyl laurate synthesis. system examined terms its capability provide an appropriate environment where will maintain ac...

Transdermal drug delivery is an alternative route for systemic drug delivery which minimizes the absorption and increases the bioavailability. Orally Clopidogrel bisulfate has a short elimination half-life (7-8 hrs.), low oral bioavailability (50%) undergoes extensive first pass metabolism (85%) and frequent high doses (75 mg) are required to maintain the therapeutic level as a result, dose dev...

The development of oral sustained or controlled release dosage form of captopril has been an interested topic of research for a long period of time. Difficulties encountered on the fact that the drug is freely water soluble. Such drug is difficult to be delivered orally in a sustained or controlled release manner and, Due to its effectiveness and intensive use as a drug of choice in the treatme...

A baby full term born of LSCS to a otherwise healthy mother was referred for ophthalmology department. On ophthalmological torch light examination, the patient had equal upper and lower lid bilateral ectropion. There missing eye lashes noted. The anterior segment evaluation found be within normal limit without evidence corneal opacities. Lamellar ichthyosis termed as Collodion is infrequent dis...

Purpose: To formulate matrix type sustained-release (SR) tablets of tizanidine hydrochloride (TH) for prolonged drug release and improvement in motor activity after spinal injuries. Methods: Matrix tablets were prepared by the wet granulation method using four polymers (hydroxyl propyl methyl cellulose [HPMC] K 100, ethyl cellulose [EC], guar gum, and polyvinylpyrrolidone (PVP K30) and characte...

Submit Manuscript | http://medcraveonline.com Abbreviations: HPMC: Hydroxypropyl Methylcellulose; MC: Methylcellulose; PLGA: Poly (Lactide-co-Glycolide); CAP: Cellulose Acetate Phthalate; LCST: Low Critical Solution Temperature; UCST: Upper Critical Solution Temperature; PPO: Polypropylene Oxide; PEO: Polyethylene Oxide; MTA: Methozolamide; PNIPAAm: Poly (N-Isopropylacrylamide); GC: Guluronic A...