نتایج جستجو برای: hydroxychloroquine hcq
تعداد نتایج: 3216 فیلتر نتایج به سال:
OBJECTIVE The antimalarial agents chloroquine (CQ) and hydroxychloroquine (HCQ) are used in long-term treatment of connective tissue diseases (CTDs). A high incidence of heart conduction disorders, including bundle-branch block and incomplete or complete atrioventricular block, has been observed among patients treated with CQ. Since no data were available for HCQ, we studied electrocardiograms ...
Autophagy is a lysosome-dependent degradative process that protects cancer cells from multiple stresses. In preclinical models, autophagy inhibition with chloroquine (CQ) derivatives augments the efficacy of many anticancer therapies, but CQ has limited activity as a single agent. Clinical trials are underway combining anticancer agents with hydroxychloroquine (HCQ), but concentrations of HCQ r...
background and purpose: occular toxicity is one of the most important complications of hydroxychloroquine. not any type of treatment has so far been found and recommended for this disorder. the purpose of this study was to report some characteristics of patients with hydroxychloroquine induced retinopathy. materials and methods: from 107 patients with rheumatoid arthritis (ra) and/or systemi...
OBJECTIVE To investigate the therapeutic benefit of cyclosporin A (CSA) switching to hydroxychloroquine (HCQ) in patients with rheumatoid arthritis (RA). METHODS Thirty four patients with RA who displayed residual inflammation and disability despite partial responses to prior maximal tolerated doses of methotrexate, were included. All were treated with a staged approach using CSA for 24 weeks...
INTRODUCTION Accelerated atherosclerosis is one of the major causes of morbidity in patients with systemic lupus erythematosus (SLE). Endothelial dysfunction (ED) is considered an early marker of atherosclerosis. It is a reversible alteration, thus representing an attractive target for prevention strategies against cardiovascular disease. Studies have shown that ED occurs in patients with SLE e...
Many countries have adopted hydroxychloroquine (HCQ) or chloroquine (CQ) and azithromycin (AZ) for the treatment of COVID-19 patients at beginning pandemic are still using them. The objective this study was to measure efficacy CQ HCQ combined with AZ on patients' survival recovery in Burkina Faso, West Africa.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly transmissible and pathogenic coronavirus that emerged in late 2019 and has caused a pandemic of acute respiratory disease, named ‘coronavirus disease 2019’ (COVID-19), which threatens human health and public safety.Hydroxychloroquine (HCQ) is an anti-malaria drug; its antiviral properties are controversial,and some in vitr...
Background: Hydroxychloroquine (HCQ) is an antimalarial drug often employed in the treatment of various diseases, as a basic for prolonged period time. Materials and Methods: Screening tests were analyzed descending order early detection changes HCQ toxicity. Results: The first ocular result toxicity are those found during visual field test, typical image fundus that highlights bull’s-eye lesio...
Chloroquine (CQ) and hydroxychloroquine (HCQ) have been used to treat malaria autoimmune diseases for more than 70 years; they also immunomodulatory anticancer effects, which are linked autophagy autophagy-independent mechanisms. Herein, we review the pharmacokinetics, preclinical studies clinical trials investigating use of CQ HCQ as adjuvant agents in cancer therapy. We discuss their safety p...
Blocking autophagy with hydroxychloroquine (HCQ) augments cell death associated with alkylating chemotherapy in preclinical models. This phase I study evaluated the maximum tolerated dose (MTD), safety, preliminary activity, pharmacokinetics, and pharmacodynamics of HCQ in combination with dose-intense temozolomide (TMZ) in patients with advanced solid malignancies. Forty patients (73% metastat...
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