نتایج جستجو برای: hyperammonemia
تعداد نتایج: 980 فیلتر نتایج به سال:
Valproic acid is a broad-spectrum anticonvulsant that has also gained attention in the psychiatric setting. With respect to safety, valproic acid may induce a seemingly rare condition, hyperammonemia, which can induce a wide variety of symptoms ranging from irritability to coma. The proposed mechanism of hyperammonemia involves depletion of carnitine and overproduction of a toxic metabolite, 4-...
Patients experiencing acute elevations of ammonia present to the ICU with encephalopathy, which may progress quickly to cerebral herniation. Patient survival requires immediate treatment of intracerebral hypertension and the reduction of ammonia levels. When hyperammonemia is not thought to be the result of liver failure, treatment for an occult disorder of metabolism must begin prior to the co...
N-Carbamylglutamate Accelerates Ureagenesis in Patients with Hyperammonemia N Ah Mew, E Daikhin, R McCarter, I Payan, I Nissim, M Yudkoff, M Tuchman Children's Research Institute, Children's National Medical Center, Washington, DC, Children's Hospital of Philadelphia, Philadelphia, PA The urea cycle is responsible for nitrogen regulation and balance in humans. Disruption of normal urea cycle fu...
Recently, Ghallab and colleagues have identified a novel strategy to reduce hyper-ammonemia in mice (Ghallab et al., 2015). The authors reduced blood ammonia concentrations by infusing a cocktail of glutamate dehydrogenase and its cofactors alpha-ketoglutarate and NADPH. This approach may be clinically relevant, because therapy of hyperammonemia is challenging (Levesque et al., 1999; Enns et al...
Original article Hyperammonemia Cholesterol Ammonia Triglycerides Phospholipids Free fatty acids Pongamia pinnata
The combination of valproic acid and topiramate has been shown to increase the risk of encephalopathy.1-5 Certain authors have proposed that this combination evokes a synergistic mechanism that produces hyperammonemia, which in turn results in encephalopathy.2,6 Described here is a case of encephalopathy potentially induced by the combination of valproic acid and topiramate, in which serial ser...
Fibrolamellar hepatocellular carcinoma is a rare hepatocellular tumor usually arising in noninfected and noncirrhotic livers. Only 2 cases accompanied by hyperammonemia due to intrahepatic shunting have been reported. A 23-year-old white woman presented with a 2-week history of nausea, vomiting, generalized weakness, and intermittent right upper quadrant pain. Abdominal computerized tomography ...
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