BACKGROUND Diabetic foot ulceration is common, affecting 1.0%-4.1% of diabetic persons per year and up to 25% in a lifetime. Diabetic foot ulcers are multifactorial in origin, and many are slow to heal and/or are complicated by infection, frequently leading to amputation. Hyperbaric oxygen therapy has been suggested for numerous indications, and it is recognized by funding agencies for a smalle...

OBJECTIVES The aim of this review is to identify clinical conditions currently treated in a pediatric population referred to the Alfred hyperbaric unit, to describe outcomes, and detail any complications occurring during treatment or transfer between units. DESIGN Retrospective, noncontrolled, clinical study. SETTING Adult hyperbaric unit in a university hospital. PATIENTS Children aged <...

We studied the effects of graded exposure to hyperbaric (1,875 mm Hg) oxygen therapy in an acute stroke model prepared by unilateral carotid artery interruption in gerbils. Pentobarbital alone, superoxide dismutase alone, two periods of hyperbaric oxygen alone, and each agent combined with hyperbaric oxygen were administered to investigate possible mechanisms of protection from cerebral ischemi...

BACKGROUND Constriction of the sciatic nerve by loose ligation produces an inflammatory neuropathic injury. This represents an animal model for peripheral mononeuropathy. Oxygen-derived free radicals are suspected to play an important role in the pathogenesis of ischemia/reperfusion injury, leading to neurogenic inflammation. Hyperbaric oxygen (HBO) has been used anecdotally to treat clinically...

The effects of hyperbaric oxygen and hypotension on postischemic cerebral edema were studied in cats. The middle cerebral artery (MCA) was transorbitally occluded for 3 hours and reperfused for 3 hours, and cats whose cortical blood flow (CoBF) decreased to lower than 10 ml/100 g/min with MCA occlusion were included in the study. Ten cats were used as controls, six were in the hypotension group...

INTRODUCTION It is difficult to evaluate the effect of drugs clinically used for idiopathic sudden sensorineural hearing loss, mainly because its underlying mechanism remains unknown. OBJECTIVE This study assessed the efficacy of hyperbaric oxygen therapy or ozone therapy in the treatment of idiopathic sudden sensorineural hearing loss, when either therapy was included with steroid treatment....

Hyperbaric oxygen therapy for the treatment of neonatal hypoxic-ischemic brain damage has been used clinically for many years, but its effectiveness remains controversial. In addition, the mechanism of this potential neuroprotective effect remains unclear. This study aimed to investigate the influence of hyperbaric oxygen on the proliferation of neural stem cells in the subventricular zone of n...

Thom SR. Oxidative stress is fundamental to hyperbaric oxygen therapy. J Appl Physiol 106: 988 –995, 2009. First published October 9, 2008; doi:10.1152/japplphysiol.91004.2008.—The goal of this review is to outline advances addressing the role that reactive species of oxygen and nitrogen play in therapeutic mechanisms of hyperbaric oxygen. The review will be organized around major categories of...

oxygen. Anecdotal reports of alternative approaches have not been followed up.'0 There is little evidence from clinical studies that normobaric oxygen is effective, and even the evidence concerning hyperbaric oxygen is difficult to interpret despite animal studies and cellular research which provide strong evidence in its favour. One important factor is that it reduces free radical concentratio...

BACKGROUND The use of hyperbaric oxygen for children with cerebral palsy has spread worldwide, despite little scientific evidence of efficacy. We did a randomised trial to assess the efficacy and side-effects of this form of therapy in children with cerebral palsy. METHODS 111 children with cerebral palsy aged 3-12 years were randomly assigned hyperbaric oxygen (n=57) or slightly pressurised ...