introduction: this study aimed to assess the incidence of breastfeeding-associated hypernatremia and related risk factors among hospitalized hyperbilirubinemic neonates. methods: this prospective study was conducted at nemazee hospital affiliated to shiraz university of medical sciences during one year to determine the association between hypernatremia (serum sodium concentration of >150 meq/l)...

BACKGROUND Phototherapy is believed to be a safe method for the management of hyperbilirubinemia. However, there are some controversial issues regarding the genotoxic effects of phototherapy on DNA. The aim of this study was to investigate morphologically both phototherapy-induced DNA double-strand breaks (DSBs) and apoptosis in lymphocytes derived from jaundiced and non-jaundiced neonates. M...

BACKGROUND Phenylhydrazine, a hemolytic agent, is widely used as a model of experimental hyperbilirubinemia. Palm tocotrienol-rich fraction (TRF) was shown to exert beneficial effects in hyperbilirubinemic rat neonates. AIM To investigate the effects of palm TRF supplementation on hepatic bilirubin-metabolizing enzymes and oxidative stress status in rats administered phenylhydrazine. METHOD...

BACKGROUND The existing therapeutic methods for neonatal jaundice are costly, time-consuming and potentially risky. Zinc salts can reduce phototherapy duration by precipitating unconjugated bilirubin in the intestine (bilirubin and zinc can form a complex in physiologic pH); however, zinc toxicity is an issue that must be considered since theoretically bilirubin reduction by phototherapy may in...

The involvement of the canalicular multidrug resistance protein 2 (Mrp2) in the hepatobiliary excretion of acetaminophen (APAP)-glutathione (GSH) conjugate and its derivatives was investigated using transport-deficient (TR- rats. Although no differences in the biliary concentration of APAP itself were detected between normal Wistar and TR- rats, significant differences in the biliary dispositio...

The biliary excretion of several organic anions is mediated by the canalicular multispecific organic anion transporter (cMOAT), which is hereditarily defective in mutant rats such as Eisai hyperbilirubinemic rats (EHBR). In addition, using a kinetic study with isolated canalicular membrane vesicles, we recently suggested the presence of ATP-dependent organic anion transporter(s) other than cMOA...

Crigler-Najjar type 1 disease (CN-1) is a genetic disorder characterized by high levels of unconjugated bilirubin due to the absence of hepatic UDPglucuronosyltransferase (UGT1) activity. Here we show that in vivo neonatal hepatocyte transduction with a lentiviral vector expressing the defective enzyme resulted in long-term correction in Gunn rats, a model of CN-1. Lentiviral vectors harboring ...

background: jaundice is one of the most common problems occurring in the neonatal period. it is commonly managed by phototherapy with its inherent complications. however, this treatment modality may itself result in the development of hypocalcaemia and create serious complications including convulsion and related conditions. objective: to determine the effect of phototherapy on serum calcium le...

bakground: phototherapy plays a significant role in the treatment and prevention of hyperbilirubinemia as well as the management of subsequent complications in the newborn.  however, this treatment modality may itself result in the development of hypocalcaemia and create serious complications including convulsion and related conditions.   objective: this study was under-taken to investigate pho...