Backgroud: Heterozygous familial hypercholesterolemia are either classical cases with high LDL-C levels, tendon xanthomas and LDL receptor gene mutation or probable cases with hypercholesterolemia without known LDL receptor gene mutations. Aims & Objectives: This study was done to compare the severity of hypercholesterolemia and risk of CVD in classical and probable cases of heterozygous famili...

AIM In spite of ample research about a high level of cholesterol in the blood of patients with colorectal cancer (CRC), the relationship between factors causing hypercholesterolemia and factors leading to CRC development is not fully investigated. The purpose of this article is to provide a review of the current research about the risk factors leading to the development of hypercholesterolemia ...

Hypercholesterolemia is a common health problem with increasing prevalence in many countries. A comprehensive evaluation of patients presenting with lipid disorders is warranted to obtain a definite diagnosis and apply the most appropriate treatment. Hypercholesterolemia is sometimes attributed to secondary causes, such as diabetes mellitus, hypothyroidism, cholestasis, chronic kidney disease, ...

Hypercholesterolemia is well established as a major risk marker for atherosclerosis and resultant cardiovascular disease. Recent studies suggest that platelets are intimately involved not only in thrombosis after plaque rupture, but also in the earliest events in the atherogenic process.1 In this issue of Arteriosclerosis, Thrombosis, and Vascular Biology, Tailor and Granger2 establish another ...

Familial hypercholesterolemia (FH) is an autosomal dominant genetic disorder with a very high prevalence of almost 1 in 200-500 people. Genetic testings have commonly revealed mutations genes namely LDLR, APOB, and PCSK9. In order to provide better management minimize the risk premature Coronary heart disease (CHD) affected people, early identification FH patients screening their first-degree r...

Hypercholesterolemia is a condition in which cholesterol concentrations the blood exceed normal levels, resulting death if total levels 240 mg/dl. The purpose of this study was to determine effect cupping therapy on hypercholesterolemia patients at Islamic Medication Clinic Reflection and Cupping Samarinda. This quantitative with pre-experimental group combined pre-test post-test groups. number...

conclusions these results demonstrate that the hypolipidemic and antioxidative effects of aqueous extract of e. caryophyllus might be due to its ability to ameliorate lipid profiles, enhance antioxidant activities, and delay the lipid peroxidation process. this confirms the previously identified protective roles of e. caryophyllus in human health. background eugenia caryophyllus (clove) is an i...

rising obesity incidence and its complications have lead to change of our view about cardio-metabolic risk factors and need of reassessment of these complications in childhood age. the aim of current study was to evaluate prevalence of obesity and related cardio-metabolic risk factors of children. this was a cross-sectional study in a representative sample of 12 years old children in rasht, the...

BACKGROUND We studied the effects on and possible interaction of balloon denudation and hypercholesterolemia on large arteries in the rabbit with special regard to structure and vascular reactivity. METHODS AND RESULTS New Zealand White rabbits fed a 1% cholesterol diet or a standard diet for 14 weeks underwent balloon denudation of the left iliac artery 4 weeks before death. Both the balloon...

BACKGROUND Hypercholesterolemia induces functional and structural changes of the microvasculature and reduces coronary flow reserve in humans and experimental animals. The effect of hypercholesterolemia on left ventricular (LV) function in the absence of coronary stenosis is, however, unknown. Our objective was therefore to assess the effect of hypercholesterolemia and cholesterol withdrawal on...