Atrial fibrillation is the commonest sustained cardiac rhythm abnormality, leading to substantial mortality and morbidity from stroke, thromboembolism and heart failure. Whilst the benefits of antithrombotic therapy in preventing stroke in atrial fibrillation are increasingly recognised, further developments in thromboprophylaxis are needed, especially since warfarin confers the inconvenience o...

to refer to them as they represent different patient populations to our own. However, we agree that, as we did not present data on the diurnal variation in soluble P-selectin and soluble thrombomodulin in healthy subjects, we were perhaps premature to interpret this data in terms of “loss” of a pattern in the patients with AF, although this lack of diurnal variation is in keeping with our hypot...

A case of central retinal artery occlusion in a patient with a 10-year history of unexplained thromboembolic disease due to a secondary hypercoagulable state is presented. Ophthalmological examination led to the final diagnosis.

Cerebral thromboembolic stroke in the young is uncommon. Disturbances in the n ormally existing dynamic equilibrium between coagulation and fibrinolysis may play a major role in the pathogenesis of such episodes. In a search for a possible hypercoagulable state platelet adhesiveness by the method of Eastham, plasma fibrinogen and euglobulin clot lysis times were estimated in 46 patients. A grou...

Platelet function was assessed in 40 patients with nephrotic syndrome but without renal failure in order to establish whether or not there is any haemostatic disorder lending to hypercoagulable state. The findings were compared with those from 40 normal controls. There was no clinical evidence of thromboembolic phenomena in the patients. Values for the mean platelet counts and clot retraction w...

INTRODUCTION The prevalence and clinical spectrum of mesenteric venous thrombosis (MVT) in India is largely unknown. METHODS We retrospectively re-viewed the case records of patients with primary mesenteric venous thrombosis seen over a 10-year period and retrieved information on clinical picture, underlying hypercoagulable states and outcome. RESULTS The 28 cases (mean age 41.2 [SD 10.2] y...