نتایج جستجو برای: hypereosinophilic syndrome

تعداد نتایج: 622015  

Journal: :The New England journal of medicine 2008
Marc E Rothenberg Amy D Klion Florence E Roufosse Jean Emmanuel Kahn Peter F Weller Hans-Uwe Simon Lawrence B Schwartz Lanny J Rosenwasser Johannes Ring Elaine F Griffin Ann E Haig Paul I H Frewer Jacqueline M Parkin Gerald J Gleich

BACKGROUND The hypereosinophilic syndrome is a group of diseases characterized by persistent blood eosinophilia, defined as more than 1500 cells per microliter with end-organ involvement and no recognized secondary cause. Although most patients have a response to corticosteroids, side effects are common and can lead to considerable morbidity. METHODS We conducted an international, randomized,...

Faranak Niknafs Fariba Ghalamkarpour Shima Younespour

Background: Erythroderma is an inflammatory disorder. It has various differential diagnoses, among which one of the most important is mycosis fungoides. Erythroderma itself can be a challenging disorder. Diagnosis of a mycosis fungoides patient presenting with erythroderma specially requires a careful assessment of the peripheral blood. Studies such as CD markers can lead to a more accura...

Journal: :Haematologica 2015
Guillaume Lefèvre Marie-Christine Copin Christophe Roumier Hélène Aubert Martine Avenel-Audran Nathalie Grardel Stéphanie Poulain Delphine Staumont-Sallé Julien Seneschal Gilles Salles Kamel Ghomari Louis Terriou Christian Leclech Chafika Morati-Hafsaoui Franck Morschhauser Olivier Lambotte Félix Ackerman Jacques Trauet Sandrine Geffroy Florent Dumezy Monique Capron Catherine Roche-Lestienne Alain Taieb Pierre-Yves Hatron Sylvain Dubucquoi Eric Hachulla Lionel Prin Myriam Labalette David Launay Claude Preudhomme Jean-Emmanuel Kahn

The CD3(-)CD4(+) lymphoid variant of hypereosinophilic syndrome is characterized by hypereosinophilia and clonal circulating CD3(-)CD4(+) T cells. Peripheral T-cell lymphoma has been described during this disease course, and we observed in our cohort of 23 patients 2 cases of angio-immunoblastic T-cell lymphoma. We focus here on histopathological (n=12 patients) and immunophenotypic (n=15) char...

2000
Jae Hoon Lim Won Jae Lee Dong Ho Lee Kyung Jin Nam

OBJECTIVE The purpose of this study was to describe the CT findings of hepatic hypereosinophilic syndrome in which hepatic lobes or segments were involved. MATERIALS AND METHODS Seven patients with hypereosinophilic syndrome with hepatic lobar or segmental involvement were included in our study. In all seven, diagnosis was based on liver biopsy and the results of corticosteroid treatment. CT ...

Journal: :The New England journal of medicine 2008
Michael E Wechsler

The role of eosinophils in common diseases — such as asthma, parasitic disease, or allergic reactions — remains speculative. Even more puzzling is the eclectic group of rare disorders that constitute the hypereosinophilic syndromes. These syndromes are characterized by persistently high levels of blood eosinophils and their toxic mediators (e.g., eosinophilic cationic protein and eosinophil-der...

Journal: :Archives of pathology & laboratory medicine 2013
Nathan D Montgomery Cherie H Dunphy Micah Mooberry Andrew Laramore Matthew C Foster Steven I Park Yuri D Fedoriw

CONTEXT The advent of molecular tools capable of subclassifying eosinophilia has changed the diagnostic and clinical approach to what was classically called hypereosinophilic syndrome. OBJECTIVES To review the etiologies of eosinophilia and to describe the current diagnostic approach to this abnormality. DATA SOURCES Literature review. CONCLUSION Eosinophilia is a common, hematologic abno...

2013
Joanna Lim Alexander Sternberg Nathan Manghat Steve Ramcharitar

BACKGROUND An 81 year old female patient diagnosed with a chronic low grade hypereosinophilic syndrome presented with angina and dyspnoea. CASE PRESENTATION She was managed for a non-ST elevated myocardial infarction since her troponin levels were elevated. On day 5, she suffered an acute clinical deterioration with type I respiratory failure and cardiogenic shock, accompanied by deterioratio...

Journal: :Haematologica 2004
Mario Cazzola

137 interleukin-5-producing T cells in idiopathic eosinophilia. New Engl J Med 1999;341:1112-20. 7. Roufosse F, Schandene L, Cogan E. Idiopathic eosinophilia. N Engl J Med 1999;342:660. 8. Bassan R, Locatelli G, Borleri G, Salvi A, Barbui T. Immunophenotypic evaluation of circulating T-cell clones in hypereosinophilic syndromes with or without abnormal CD3 and CD4 lymphocytes. Haematologica 200...

2011
S. Dujardin R. Schots S. De Raedt

We describe a case of suspected "T-cell-mediated" hypereosinophilic syndrome presenting with cerebral watershed infarcts. An extensive search for potential embolic sources was negative, supporting the hypothesis that cerebrovascular endothelial dysfunction could have caused the infarcts.

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