نتایج جستجو برای: hyperestrogenism
تعداد نتایج: 90 فیلتر نتایج به سال:
Companion animals, including bitches, may be exposed to zearalenone (ZEN) toxins that are often present in feed, and ZEN intoxication may lead to ovarian dysfunction. This study involved evaluation of the degree of ZEN-induced hypo stimulation of ovary by determination of proliferative and apoptotic indices and description of the ultra-structural organization of ovarian follicles in pre-puberta...
CONTEXT Peutz-Jeghers syndrome (PJS) is an autosomal-dominant disorder that arises as a consequence of mutations in the STK11 gene that encodes LKB1. PJS males often have estrogen excess manifesting as gynecomastia and advanced bone age. We and others have previously described an increase in testicular aromatase expression in PJS patients. However, the underlying mechanism has not yet been expl...
Abstract Hyperestrogenism may cause erectile dysfunction(ED) by impeding normal penile development,increasing venous vascular permeability and leakage(via VEGF) inhibiting testosterone(T)production. Estrogen excess can impair spermatogenesis increase the risk of estrogen-sensitive cancers(viz.breast cancer)[1,2]Weekly biweekly letrozole(2.5 mg),an aromatase inhibitor,has been reported to normal...
BACKGROUND Contrasting etiologic hypotheses about the role of endogenous sex steroids in breast cancer development among premenopausal women implicate ovarian androgen excess and progesterone deficiency, estrogen excess, estrogen and progesterone excess, and both an excess or lack of adrenal androgens (dehydroepiandrosterone [DHEA] or its sulfate [DHEAS]) as risk factors. We conducted a case-co...
Аbstract. Relevance. The number of women older reproductive age is steadily increasing, and repeated failures Assisted Reproductive Technologies programs during the transfer high-quality embryos indicate possibility disruption embryo implantation processes associated with impaired receptivity functionality endometrium. Morphological, immunological immunohistochemical changes in endometrium fact...
The most pathological conditions that adversely affect the reproductive function in men of mature age is formed precisely adolescence as a result from hypoandrogenism (HA), - decrease production male sex hormones (androgens) below norm. Therefore, ability to predict course HA adolescent boys allows prevent serious health problems future. Purpose determine significant prognostic criteria for adv...
Endogenous estrogens can be bio-activated to endogenous carcinogens via formation of estrogen quinones. Estrogen-3,4-quinones react with DNA to form mutagenic depurinating estrogen-DNA adducts. The carcinogenicity of endogenous estrogens is related to unbalanced estrogen metabolism leading to excess estrogen quinones and formation of depurinating DNA adducts. The present studies were initiated ...
BACKGROUND Obesity has been associated with increased mortality from hormone dependant cancers such as breast cancer which is the most prevalent cancer in women. The link between obesity and breast cancer can be attributed to excess estrogen produced through aromatization in adipose tissue. The role of steroid hormone receptors in breast cancer development is well studied but how obesity can af...
Cases included in a population-based case-control study of breast cancer in men were recruited from 10 geographic areas of the United States from 1983 to 1986. Controls, matched to cases on age and geographic area, were selected by random digit dialing for men under age 65 years and from Health Care Financing Administration files for older men. Results are based on responses from 227 cases and ...
BACKGROUND Carcinoma of the male breast is responsible for less than 1% of all malignancies in men but the incidence is rising. Invasive ductal carcinoma is the most common histological subtype while invasive lobular carcinoma is responsible for only 1.5% of the total cases of which pleomorpic lobular carcinoma is an extremely rare variant. We report the case of a gentleman with node positive, ...
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