This study elucidates the nature of melanogenesis in B16 and Harding-Passey (HP) mouse melanomas producing melanin and melanosomes of different color and fine structure, i.e., brownblack eumelanosome-like B16 granules and reddish brown pheomelanosome-like HP granules, and compares them with "typical" 3,4-dihydroxyphenylalanine (DOPA) and sepia eumelanins and sepia eumelanosomes. The melanin con...

Focal epithelial hyperplasia (FEH) or Heck’s disease is a rare viral infection of the oral mucosa caused by human papilloma virus especially subtypes 13 or 32. The frequency of this disease varies widely from one geographic region and ethnic groups to another. This paper reports an Iranian case of extensive focal epithelial hyperplasia. A 35-year-old man with FEH is described, in whom the lesio...

  Introduction: The process of discriminating among benign and malignant hyperplasia begun with subjective methods using light microscopy and is now being continued with computerized morphometrical analysis requiring some features. One of the main features called Volume Percentage of Stroma (VPS) is obtained by calculating the percentage of stroma texture. Currently, this feature is calculated ...

background : insulin-like growth factor-1 can act in both an autocrine and paracrine manner to promote normal growth and malignant cellular proliferation. the importance of this factor as a major regulatory peptide has been established for cells, in vitro and in vivo. however, the role of serum insulin-like growth factor-1 levels in the etiology of benign prostatic hyperplasia and prostate canc...

background and objectives: endometrial hyperplasia (eh) is an abnormal overgrowth of endometrium that may lead to endometrial cancer, especially when accompanied by atypia. the treatment of eh is challenging, and previous studies report conflicting results. metformin (dimethyl biguanide) is an anti-diabetic and insulin sensitizer agent, which is supposed to have antiproliferative and anticancer...

background: assessment of uterine abnormalities is a core part in infertility evaluation. objective: the aim of this study was to evaluate the sensitivity and specificity of three-dimensional hysterosonography (3-dhs) in the diagnosis of uterine abnormalities in infertile women. materials and methods: the infertile women who visited royan institute and referred to 3-dhs consecutively, prior to ...

Background and Objectives: Endometrial hyperplasia (EH) is an abnormal overgrowth of endometrium that may lead to endometrial cancer, especially when accompanied by atypia. The treatment of EH is challenging, and previous studies report conflicting results. Metformin (dimethyl biguanide) is an anti-diabetic and insulin sensitizer agent, which is supposed to have antiproliferative and anticancer...

background: endometrial cancer is the most common gynecologic malignancy that has often proceeded by a premalignant phase. modern molecular and immune staining methods for precancerous lesions diagnosis have been expanded. one of the genetic alternations in the endometrial cancer carcinogenesis is the mutational activation of the k-ras oncogene. k-ras mutation has recognized to occur at an earl...

focal epithelial hyperplasia (feh) or heck’s disease is a rare viral infection of the oral mucosa caused by human papilloma virus especially subtypes 13 or 32. the frequency of this disease varies widely from one geographic region and ethnic groups to another. this paper reports an iranian case of extensive focal epithelial hyperplasia. a 35-year-old man with feh is described, in whom the lesio...

Cyclosporin and azathioprine are immunosuppressive drugs, used widely in kidney transplant patients. A significant association between immunosuppressive therapy and multiple warts was described several years ago. There are also some reports of sebaceous gland hyperplasia in kidney transplant patients receiving cyclosporin. We report herein a 57-year-old woman who developed multiple warts on her...