Purpose — to discover peculiarities of Wilson disease course in children dependently on the variant liver affection. Materials and methods. Anamnesis clinical paraclinical with consideration affection severity have been studied 50 aged 5–17 years. Results. It was estimated that 52% had a form chronic hepatitis minimal symptoms, 44% patients cirrhosis predominant signs edematous ascitic syndrome...

We report the case of an 82-years-old man with a history of hypertension, smoker and drinker of alcohol who was diagnosed with cirrhosis by abdominal ultrasound for hypertransaminasemia. In the same test, three hepatic lesions were observed, and by computerized tomography a multicenter HCC was diagnosed, being the largest of these lesions 55 mm in size. The patient had compensated cirrhosis (Ch...

We present the 12-month results of a prospective trial of conversion from calcineurin inhibitors (CNI) to everolimus (EVL) in maintenance liver transplant (LT) recipients. Forty (M:F = 28:12; 54.9 +/- 11 years) patients were enrolled at a mean interval of 45.5 +/- 31.2 months from transplantation. Conversion was with EVL at a dosage of 0.75 mg b.i.d., withdrawal of antimetabolites, and a 50%-pe...

Recent studies report a prevalence of non-alcoholic fatty liver disease (NAFLD) of between 70% and 80% in patients with metabolic syndrome (MS) and type 2 diabetes mellitus (T2DM). Nevertheless, it is not possible to differentiate between simple steatosis and non-alcoholic steatohepatitis (NASH) with non-invasive tests. The aim of this study was to differentiate between simple steatosis and NAS...

BACKGROUND/AIM A cryptogenic elevation of transaminases is the most common hepatic manifestation in celiac disease (CD). In adult patients and pediatric patients with cryptogenic hypertransaminasemia, the prevalence of CD was 4% and 12%, respectively. However, there are no related data from China in this regard. We aimed to investigate the status of CD in young Chinese patients with elevated tr...

Today the knowledge of genotype-phenotype correlation in cystic fibrosis is enriched by the growing discoveries of new mutations of the CFTR gene. Although the combination of two severe mutations usually leads to the classic disease (pulmonary and pancreatic insufficiency, sterility, nasal polyposis), the presence of a complex genotype characterized by severe and milder mutations or polymorphis...

To get insight into still elusive pathomechanisms of pediatric obesity and non-alcoholic fatty liver disease (NAFLD) we explored the interplay among GC-MS studied urinary metabolomic signature, gut liver axis (GLA) abnormalities, and food preferences (Kid-Med). Intestinal permeability (IP), small intestinal bacterial overgrowth (SIBO), and homeostatic model assessment-insulin resistance were in...

1699-258X/$ see front matter © 2010 Elsevier España, S.L. All rights reserved. We present the case of a 50 year old woman who was diagnosed with undifferentiated connective tissue disease (UCTD), based on severe Raynaud’s phenomenon with ischemic ulcers, extensive calcinosis, sclerodactilia, polyarthritis, glomerulonephritis, polyserositis, chronic hypertransaminasemia and had undergone the bil...

INTRODUCTION The therapy of patients with psoriasis and liver disease can be a challenge due to the increased risk of adverse effects from traditional systemic treatments; in addition, although the anti-tumor necrosis factor agents are considered safer, they have also been associated with drug-induced liver injury and reactivation of viral hepatitis. Ustekinumab has a different mechanism of act...