Abstract Background The purpose of this study was to assess the metabolic abnormalities in high-risk stone formers. Methods This a retrospective observational done at Tribhuvan University Teaching Hospital, Nepal, over 1-year period. High-risk formers were identified and evaluated with serum chemistries 24-h urinary chemical evaluation. Stone analysis also included whenever available. Common re...

Medullary Nephrocalcinosis (MNC) is defined as calcium deposition in tubular basement membrane and interstitium of the kidney medulla. It 20 times more common than cortical one. In this case report, we present a 12-year-boy who presented with persistent nocturnal enuresis for 8 years. Physical examination routine tests were normal except microscopic hematuria. Renal ultrasound showed extensive ...

Urinary citrate concentration, a major factor in the formation of kidney stones, is primarily determined by its rate of reabsorption in the proximal tubule. Citrate reabsorption is mediated by the Na-dicarboxylate cotransporter-1 (NaDC-1). The opossum kidney (OKP) cell line possesses many characteristics of the renal proximal tubule. The OKP NaDC-1 (oNaDC-1) cDNA was cloned and encodes a 2.4-kb...

High dietary protein intake generates endogenous acid production, which may adversely affect bone health. Alkaline potassium citrate (Kcit)(2) may contribute to the neutralization of the protein-induced metabolic acidosis. We investigated the impact of 2 levels of protein intake and Kcit supplementation on acid-base metabolism and bone status in rats. Two-month-old Wistar male rats were randoml...

Objectives. Considering the differences in location, socioeconomic background, and cultural background, the aim of this study was to try to identify possible factors associated with the increased incidence of urolithiasis by comparing American and Brazilian children with stones. Methods. Data of 222 American and 190 Brazilian children with urolithiasis were reviewed including age, gender, body ...

Intended Audience: Pediatrics; Nephrology Outpatient Clinic; Children With Kidney Stones RENAL STONE DISEASE, or nephrolithiasis, is a major health concern associated with significant pain, morbidity, and medical cost. Recurrent nephrolithiasis can lead to chronic kidney disease, as well as increased risk of related conditions such as cardiovascular disease and fracture. The incidence of nephro...

OBJECTIVE To evaluate the prevalence of metabolic disorders in patients with staghorn calculi treated at the Regional Center of Lithiasis Metabolic Studies in central region of Såo Paulo State, Brazil. MATERIALS AND METHODS Between February 2000 and February 2008, 630 patients with urinary calculi were evaluated in the lithiasis outpatient clinic. Thirty-seven of them had staghorn calculi (35...