Plasma total bilirubin for a 65-year-old man was high [19.1 mg/dL (326 mol/L)] on a Roche cobas 6000 analyzer. However, the specimen was anicteric and the icteric index was 1 (approximately 1 mg/dL or 17 mol/L). A dilution study demonstrated nonlinear results. Direct bilirubin was measured as normal. The split specimen aliquots were further measured on analyzers from 5 different manufacturers (...

Objective We aimed to find new methods to detect and quantify hemolysis and icterus which may cause assay biases. These methods need to determine each of these interferents in the presence of various other interferents. They also need to have less stringent requirements in development and implementation than those conventional analyzers currently must satisfy. Design and methods We developed tw...

There was no past history of any significance. Present illness.?Some twenty-five days previously he experienced a chill, followed by fever and cough with expectoration unci general body pain. About fourteen days ago he noticcd jaundice and dark coloration oi his urine, succeeded by epigastric pain and constipation. Condition on admission.?\\ ell made and nutrition good. Appetite good. Deep icte...

We present a 12-year old boy with jaundice for 2 weeks. The child was deeply icteric and had hepatomegaly. IgM antibodies for hepatitis A virus were positive. However this child had prolonged cholestasis and cholestyramine was started. The child responded only after prednisolone was started.

In Western Nigeria samples of serum or plasma are often bright yellow and yet have normal levels of bilirubin. In a pilot experiment in 1959 we found that unusually high levels of total carotenoids were present in several samples of yellow serums. Edozien (1960) has since reported values for serum carotene in Ibadan ranging from 150 to 900 pg/Ioo ml in normal individuals, compared with the figu...