Insulin degradation is a regulated process that plays a role in controlling insulin action by removing and inactivating the hormone. Abnormalities in insulin clearance and degradation are present in various pathological conditions including type 2 diabetes and obesity and may be important in producing clinical problems. The uptake, processing, and degradation of insulin by cells is a complex pr...

It was proposed that insulin-degrading enzyme (IDE) participates in the clearance of amyloid beta (Abeta) in the brain, and its low expression or activity may be relevant for the progression of Alzheimer disease. We performed a longitudinal study of brain level, activity, and distribution of IDE in transgenic mice (Tg2576) expressing the Swedish mutation in human Abeta precursor protein. At 16 ...

This work proposes the Improved Differential Evolution (IDE) for single objective optimization problems with continuous variables. The proposed IDE uses improved Differential Evolution (DE) operators (mutation and crossover) in order to explore the state space of possible solutions with greater effectiveness, as well as to accelerate its convergence speed. Furthermore, an experimental analysis ...

The prevalence of iron depletion, iron deficient erythropoiesis (IDE), and iron deficiency anemia (IDA) was assessed in preschool Inuit children using soluble transferrin receptor (sTfR) and traditional indicators of iron status while disregarding or taking inflammation into account when defining SF cutoffs. Iron depletion was defined as follows: (1) SF < 15 μg/L regardless of the C-reactive pr...

This paper addresses the problem of IDE interface complexity by introducing single-window graphical user interface. This approach lies in removing additional child windows from IDE, thus allowing a user to keep only text editor window open. We describe an abstract model of IDE GUI that is based on most popular modern integrated environments and has generalized user interface parts. Then this ab...

A. Motivated by the hierarchical multiscale image representation of Tadmor et. al., [25], we propose a novel integro-differential equation (IDE) for a multiscale image representation. To this end, one integrates in inverse scale space a succession of refined, recursive ‘slices’ of the image, which are balanced by a typical curvature term at the finer scale. Although the original motivati...

Insulin degrading enzyme (IDE) exists primarily as a dimer being unique among the zinc metalloproteases in that it exhibits allosteric kinetics with small synthetic peptide substrates. In addition the IDE reaction rate is increased by small peptides that bind to a distal site within the substrate binding site. We have generated mixed dimers of IDE in which one or both subunits contain mutations...

The etioplast of dark-grown angiosperms is characterized by the prolamellar body (PLB) inner membrane, the absence of chlorophyll, and the accumulation of divinyl and monovinyl derivatives of protochlorophyll(ide) a [Pchl(ide) a]. Either of two structurally related, but differentially expressed light-dependent NADPH:Pchlide oxidoreductases (PORs), PORA and PORB, can assemble the PLB and form da...