This paper presents a probabilistic safety assessment framework based on the international standard, IEC 61508, for control laws designed especially by reliable control theory. The framework uses Markov techniques summarized in IEC 61165 to take restoration of devices into consideration. It clarifies a contribution of reliable control to risk reduction required in IEC 61508. Copyright c ©2005 IFAC

As the latest standard that is quickly gaining popularity in power substation automation, IEC 61850 offers self-descriptive object data models, standardized configurability with Substation Configuration Language (SCL), the promise of interoperations among intelligent electronic devices (IEDs) from different manufacturers, and lower integration installation costs. The IEC 61850 standard initiall...

Amifostine (AM) is a radioprotector that scavenges free radicals and is used in patients undergoing radiotherapy. p53 has long been implicated in cell cycle arrest for cellular repair after radiation exposure. We therefore investigated the protective p53-dependent mechanism of AM on small bowel damage after lethal whole-abdominal irradiation (WAI). AM increased both the survival rate of rats an...

Journal of Medical Device Regulation May 2006 The third edition of IEC 60601-1 represents a major overhaul of the IEC 60601 family of medical electrical equipment safety standards. First published in 1977, IEC 60601-1 has become the ‘bible’ of electromedical equipment safety and the parent standard of over 60 particular device standards ranging from diagnostic electrocardiographs to electron ac...

To clarify whether serum free fatty acid (FFA) is an inhibitor of extrathyroidal conversion (IEC) of thyroxine (T4) to thyronine (T3), we measured the concentration of FFA, IEC activity and thyroid hormones in normal subjects, acute ketotic children and children with low T3 syndrome due to nonthyroidal illness (NTI). Iodothyronine (I) 5'-deiodinase activity was assayed with reverse triiodothyro...

BACKGROUND Small intestinal epithelial cells (IEC) show apoptosis in physiological turnover of cells and in certain inflammatory diseases. AIMS To investigate the role of caspases in the progression of IEC apoptosis in vivo. METHODS IEC were separated along the villus-crypt axis from the jejunum of normal and Nippostrongylus brasiliensis infected rats at 4 degrees C. Caspases were examined ...

AIMS AND BACKGROUND The study focused on the evaluation of the accuracy of intracranial stereotactic radiosurgery treatments delivered with helical tomotherapy by means of the InterFix™ Radiosurgery kit. METHODS AND STUDY DESIGN Twenty-two patients received stereotactic radiosurgery treatments with single fraction dose ranging from 13 to 20 Gy depending on diagnosis. Megavoltage computed tomo...

Electrical units are operated by electrical and electronic components. An environmental test sequence is useful for testing electrical units to reduce reliability issues. This study introduces test sequence guidelines based on relevant principles and considerations for electronic testing according to International Standard IEC-60068-1 and the United States Military Standard MIL-STD-810G. Test s...