BACKGROUND We investigated the effects of gene polymorphisms on the development of IgA nephropathy and thin glomerular basement membrane (GBM) disease by analyzing polymorphisms in the interleukin (IL)-18, transforming growth factor (TGF)-β, and vascular endothelial growth factor (VEGF) genes in Korean patients. METHODS This study included 146 normal individuals and 69 biopsy-proven IgA nephr...

Several cases of concurrent Fabry's disease and IgA nephropathy have been reported, but the pathogenic association between these two diseases remains unclear. This is a report on the case of a girl with severe IgA nephropathy who was subsequently diagnosed with subclinical Fabry's disease. An 11-year-old girl was admitted to our hospital with massive proteinuria and hematuria detected by urinar...

BACKGROUND IgA nephropathy has been reported as a renal involvement in Crohn's disease. Crescentic IgA nephropathy, which accounts for fewer than 5% of cases of IgA nephropathy, has a poorer prognosis than other forms of crescentic glomerulonephritis. We recently experienced a case of rapidly progressive IgA nephropathy concurrent with exacerbation of Crohn's disease. CASE PRESENTATION An 18-...

Ankylosing spondylitis (AS) is associated with IgA nephropathy. To study the pathogenetic mechanism of this association the presence of haematuria and circulating IgA containing immune complexes (IgA ICs) in 70 patients with AS was determined. In this retrospective study haematuria was present in 15 patients and 25 patients had IgA ICs. Circulating IgA ICs were shown in 9/15 (60%) of the patien...

Subretinal Drusenoid Deposits AssociatedWith Complement-Mediated IgANephropathy Complement-mediated IgA nephropathy is themost common causeofchronicglomerulonephritisworldwide.Thepathogenesis of renal damage is related to complement activation secondary to IgA immune complex deposition in the glomerulus. To our knowledge, this is the first report of IgA nephropathy associatedwithbilateral subre...

IgA nephropathy is a primary glomerulopathy characterized by deposition of IgA containing immune deposits in the kidney. Its diagnosis is based on histopathologic and immunoflourescence studies on renal biopsy. The disorder is poorly understood. This review is focused on updates regarding its pathogenesis and discussion on a new proposed histopathological classification of IgA nephropathy.

henoch-schönlein purpura nephritis and iga nephropathy are currently considered to be different clinical presentations of the same disease. there is need for a reliable proven, morphologic classification that can help clinicians more accurately formulate treatment strategies for patients with henoch-schönlein purpura nephritis. considering that henoch-schönlein purpura nephritis and iga nephrop...

IgA nephropathy was found associated with celiac disease and dermatitis herpetiformis in a two years old male child at our center. This observed association widen the spectrum of the diseases that have been reported to coexist with IgA nephropathy.

BACKGROUND IgA nephropathy, a prevalent disease in Asia, is considered the main cause of end stage renal disease among primary glomerular disease. OBJECTIVE To determine the frequency of different clinical, histopathological and immunofluorescent characteristics of IgA nephropathy. METHODS Renal biopsies of 376 patients were received for immunofluorescent and for histopathological studies. ...

BACKGROUND The concomitant presence of idiopathic membranous nephropathy and IgA nephropathy is rare. Here, we report 9 cases of phospholipase-A2-receptor (PLA2R) positive idiopathic membranous nephritis combined with IgA nephropathy, while reviewing publications regarding the pathological characteristics of this glomerolonephritis complication. CASE PRESENTATION Nine cases of renal biopsy ti...