نتایج جستجو برای: il28b polymorphisms

تعداد نتایج: 67261  

2012
Yuji Hodo Masao Honda Akihiro Tanaka Yoshimoto Nomura Kuniaki Arai Taro Yamashita Yoshio Sakai Tatsuya Yamashita Eishiro Mizukoshi Akito Sakai Motoko Sasaki Yasuni Nakanuma Mitsuhiko Moriyama Shuichi Kaneko

Purpose: Several single nucleotide polymorphisms (SNPs) in the interleukin 28B (IL28B) locus have recently been shown to be associated with antiviral treatment efficacy for chronic hepatitis C (CH-C). However, such an association with hepatocellular carcinoma (HCC) is unknown. Here, we investigated the association between the IL28B genotype and the biology and clinical outcome of HCC patients r...

2014
Nae-Yun Heo Young-Suk Lim Woochang Lee Minkyung Oh Jiyun An Danbi Lee Ju Hyun Shim Kang Mo Kim Han Chu Lee Yung Sang Lee Dong Jin Suh

BACKGROUND/AIMS There are few available data regarding the association between the single nucleotide polymorphisms (SNPs) of the gene encoding interleukin 28B (IL28B) and a sustained virologic response (SVR) to peginterferon (PEG-IFN) plus ribavirin (RBV) therapy in Korean chronic hepatitis C patients. METHODS This was a retrospective cohort study of 156 patients with chronic hepatitis C viru...

Journal: :Journal of infection in developing countries 2017
Murat Ispiroglu Ibrahim Halil Bahcecioglu Ulvi Demirel Mehmet Yalniz

INTRODUCTION Pegylated-interferon alpha (Peg-IFN α) is the therapy most commonly used to treat chronic hepatitis delta virus (HDV) infection. In the present study, we planned to investigate effect of IL28B polymorphism on response to Peg-IFN α therapy and disease progression in patients with chronic HDV. METHODOLOGY A total of 47 patients who received Peg-IFNα therapy for at least one year we...

2013
Sreedhar Chinnaswamy Snehajyoti Chatterjee Ramachandran Boopathi Shuvolina Mukherjee Samsiddhi Bhattacharjee Tapas K. Kundu

Persistence of hepatitis C virus (HCV) infection is observed only in a subset of infected individuals and among them only some respond to treatment. Genome-wide association studies (GWAS) carried out around the world identified single nucleotide polymorphisms (SNPs) in the IL28B locus that are strongly associated with both HCV clearance and treatment response. The functional significance of the...

Journal: :Acta medica Okayama 2014
Ryuichiro Tsuzaki Akinobu Takaki Takahito Yagi Fusao Ikeda Kazuko Koike Yoshiaki Iwasaki Hidenori Shiraha Yasuhiro Miyake Hiroshi Sadamori Susumu Shinoura Yuzo Umeda Ryuichi Yoshida Daisuke Nobuoka Masashi Utsumi Eiichi Nakayama Toshiyoshi Fujiwara Kazuhide Yamamoto

It is not known how the immune system targets hepatitis C virus (HCV)-infected HLA-mismatched hepatocytes under immune-suppressed conditions after orthotopic liver transplantation (OLT). In addition, the relationship between the HCV-specific immune response and IL28B variants as predictors of HCV clearance has not been well-characterized. We determined the IL28B polymorphisms for 57 post-OLT HC...

2013
Alejandro Soza Marcelo Lopez-Lastra

Latin America is a diverse region with more than 500million people and approximately 8 million HCV infected individuals. The recent description of genetic polymorphisms associated to the interleukin 28B gene that predicts the response to treatment in these patients has impacted the clinical algorithms of management. In this review we examine the studies of prevalence of the IL28B genotypes in t...

Journal: :hepatitis monthly 0
heidar sharafi armin pathobiology laboratory, iran; tehran hepatitis cohort (thc) study center, iran ali pouryasin armin pathobiology laboratory, iran; tehran hepatitis cohort (thc) study center, iran; department of genetics, islamic azad university of arsanjan, iran +98-2188732773, [email protected]; department of genetics, islamic azad university of arsanjan, iran +98-2188732773, [email protected] seyed moayed alavian tehran hepatitis cohort (thc) study center, iran; baqiyatallah research center for gastroenterology and liver disease, baqiyatallah university of medical sciences, iran bita behnava tehran hepatitis cohort (thc) study center, iran; baqiyatallah research center for gastroenterology and liver disease, baqiyatallah university of medical sciences, iran maryam keshvari tehran hepatitis cohort (thc) study center, iran; iranian blood transfusion organization, iran shima salimi tehran hepatitis cohort (thc) study center, iran; baqiyatallah research center for gastroenterology and liver disease, baqiyatallah university of medical sciences, iran

background il28b polymorphism is recognized as one of the most prominent predictors of hepatitis c spontaneous and treatment-induced clearance. interestingly, the favorable genotypes of il28b are found to be more frequent in asian ethnicity than caucasian and african populations, respectively. a few studies reported that there is a mysterious association between the il28b polymorphism and the h...

Journal: :hepatitis monthly 0
seyed hossein aalaei-andabili molecular immunology research center, department of immunology, school of medicine, tehran university of medical sciences, tehran, ir iran bita behnava middle east liver disease center, tehran, ir iran; baqiyatallah research center for gastroenterology and liver disease (brcgl), baqiyatallah university of medical sciences, tehran, ir iran shima salimi middle east liver disease center, tehran, ir iran; baqiyatallah research center for gastroenterology and liver disease (brcgl), baqiyatallah university of medical sciences, tehran, ir iran heidar sharafi middle east liver disease center, tehran, ir iran; baqiyatallah research center for gastroenterology and liver disease (brcgl), baqiyatallah university of medical sciences, tehran, ir iran seyed moayed alavian middle east liver disease center, tehran, ir iran; iran hepatitis network (ihn), tehran, ir iran; middle east liver disease center, tehran, ir iran. tel: +98-2188067114, fax: +98-2188067114

conclusions there were significant linkages between hcv genotypes and il28b genotypes/alleles. patients with a favorable il28b and genotypes 1 and 4 hcv infection stand a better chance to clear hcv in the acute phase. objectives this meta-analysis was designed to determine the world-wide distribution patterns of il28b genotypes and alleles, and to find possible linkages between il28b and hcv ge...

Journal: :Acta medica Okayama 2014
Yuki Moritou Fusao Ikeda Yoshiaki Iwasaki Nobuyuki Baba Kouichi Takaguchi Tomonori Senoh Takuya Nagano Yasuto Takeuchi Tetsuya Yasunaka Hideki Ohnishi Yasuhiro Miyake Akinobu Takaki Kazuhiro Nouso Kazuhide Yamamoto

The impact of hepatic steatosis on interferon therapy for patients with chronic hepatitis C (CHC) has been associated with single-nucleotide polymorphisms (SNP) of IL28B, patatin-like phospholipase domain-containing protein 3 (PNPLA3), and low-density lipoprotein (LDL) receptor. Whether this holds true for Japanese patients, however, remains unresolved. The present study prospectively enrolled ...

2012
Golo Ahlenstiel David R Booth Jacob George

In the past 2 years the ability to successfully eradicate chronic HCV infection has been substantially enhanced by two landmark scientific breakthroughs. Firstly, the advent of HCV-specific direct-acting antiviral (DAA) compounds has resulted in a significant increase in sustained virological response rates in HCV genotype-1-infected treatment-naive patients and in non-responders to prior pegyl...

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