Abstract Maternal antibody-mediated fetal red blood cell destruction secondary to non-D Rh system antibodies is a significant cause of hemolytic disease the fetus and newborn. Here, we report rare case severe perinatal associated with maternal antibody e antigen. In addition anemia, infant developed hyperbilirubinemia. Resolution infant’s anemia hyperbilirubinemia occurred after treatment photo...

Autoimmune hemolytic anemia (AIHA) is most often idiopathic. However, in recent years, AIHA has been noted with increased incidence in patients receiving purine nucleoside analogues for hematologic malignancies; it has also been described as a complication of blood transfusion in patients who have also had alloimmunization. As the technology of hematopoietic stem cell transplantation has become...

We have used the complement-fixing antibody consumption ( CFAC ) test to detect small concentrations of IgG on red blood cells from patients with hemolytic anemias that are not thought to be caused by an immune mechanism. Although patients with hereditary spherocytosis, pyruvate kinase deficiency, and mechanical hemolytic anemias generally had normal concentrations of IgG bound to their red cel...

BACKGROUND Previous studies have suggested that there may be an association between some immune-mediated diseases and risk of tuberculosis (TB). METHODS We analyzed a database of linked statistical records of hospital admissions and death certificates for the whole of England (1999 to 2011), and a similar database (the Oxford Record Linkage Study (ORLS)) for a region of southern England in an...

I T IS NOW evident that the syndrome of acquired hemolytic anemia represents a distinct entity which is separate in pathogenesis and course from the commonly described familial hemolytic jaundice. This distinction, which was recognized by the writers of the early part of the century, was lost sight of by many more recent observers, who suggested that acquired hemolytic anemia was simply a sudde...

BACKGROUND Accumulating evidence suggests that transfusion of packed red blood cells (PRBCs) stored for >14 days is associated with increased rates of sepsis, multiple organ dysfunction, and mortality in human patients. OBJECTIVE To determine if duration of PRBC storage has an effect on morbidity and mortality in dogs after transfusion. ANIMALS Dogs admitted to the Matthew J Ryan Veterinary...

In most cases, immune-mediated hemolysis occurs extravascularly and is associated with IgG antibodies on the surface of red cells. Rare syndromes include IgG antibodies that cause direct intravascular hemolysis, such as paroxysmal cold hemoglobinuria. Also rare are extravascular hemolytic syndromes caused by IgM polyclonal or monoclonal antibodies that demonstrate red cell agglutination at 3 de...

Tuberculosis (TB), a common health problem in developing countries, is a specific multi-systemic infection that can lead protean manifestations in any organ system. Anemia and leukocytosis are the most frequent hematological findings at presentation and during the long clinical course of the disease. Coombs’-positive hemolytic anemia and immune thrombocytopenic purpura (ITP) are exceedingly rar...

Visceral leishmaniasis (VL) is an intracellular parasitic infection that infects and multiplies in the macrophages of the liver, spleen and bone marrow. It is characterized by intermittent fever, hepatosplenomegaly, pancytopenia and hypergammaglobulinemia. Anemia of multifactorial etiology is a usual manifestation of VL; however, Coombs positive hemolytic anemia has been infrequently reported i...

We have investigated the hemolytic mechanisms in a patient with acquired immune hemolytic anemia whose red cells appeared to be coated with IgA alone. The clinical course was similar to that of patients with hemolytic anemia mediated by warm-reacting IgG antibody. Splenic sequestration of red cells was demonstrated, and marked reduction of hemolysis occurred after corticosteroid therapy. Antibo...