Drugs can induce thrombocytopenia by several mechanisms, including marrow suppression and destruction of platelets in the peripheral blood by non-immune and immune mechanisms. We will review here current understanding of the immune mechanisms by which drugs promote immune-mediated platelet destruction resulting in thrombocytopenia.

Platelet-associated IgG (PAIgG) is elevated in idiopathic thrombocytopenic purpura (ITP), but it also is elevated in other thrombocytopenic disorders traditionally considered to be nonimmune. Consequently it is possible that elevated PAIgG is a nonspecific finding secondary to thrombocytopenia. To study this issue we developed a rabbit model of immune and nonimmune mediated thrombocytopenia. Th...

ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA KsiÄ Å¼ek A, Szczepański T. Primary immune thrombocytopenia in children. Pediatria Polska - Polish Journal of Paediatrics. 2021;96(1):53-59. doi:10.5114/polp.2021.104829. APA żek, A., & Szczepański, (2021). Paediatrics, 96(1), 53-59. https://doi.org/10.5114/polp.2021.104829 Chicago Agnieszka, and Tomasz Szczepa...

This prospective observational cohort study aimed to explore the clinical features of incident immune thrombocytopenia in adults and predictors of outcome, while determining if a family history of autoimmune disorder is a risk factor for immune thrombocytopenia. All adults, 18 years of age or older, recently diagnosed with immune thrombocytopenia were consecutively recruited across 21 hospital ...

BACKGROUND Immune thrombocytopenia is an immune disease characterized by thrombocytopenia and bleeding due to platelet antibodies against platelet membrane glycoproteins. Human platelet antigens are derived from polymorphisms of these glycoproteins. The aim of this study was to investigate human platelet antigen frequencies in immune thrombocytopenia patients from the state of Amazonas, Brazil ...