A 54-year-old white woman presented with a 3-month history of progressive painful lesions on her tongue and oral mucosa. Her primary care physician initially treated her with nystatin and hydrogen peroxide, followed a few weeks later by acyclovir (Zovirax) ointment and a rapid 5-day prednisone taper, without improvement in her symptoms. Two months after the oral lesions developed, violaceous pa...

To my precious Wura and a rare gem ………… L.A.B ii Summary Till date, there are no effective control strategies against the deadly disease of malaria, and millions of children across Africa, Oceania, Asia, and Latin America are at the mercy of this long term enemy of man every second that passes by. Other control measures combined with vaccination might help improve control strategy against malar...

Oligomeric forms of the acetylcholine receptor are directly visualized by electron microscopy in receptor-rich membranes from torpedo marmorata. The receptor structures are quantitatively correlated with the molecular species so far identified only after detergent solubilization, and further related to the polypeptide composition of the membranes and changes thereof. The structural identificati...

2-week history of progressive malaise, myalgia, fever, nausea, vomiting, diarrhea, polyuria and polydipsia. He had a history of gastresophageal reflux that did not respond to ranitidine. He had started taking oral pantoprazole (40 mg daily) 6 weeks earlier. The patient had a history of coronary artery disease and was taking acetylsalicylic acid (81 mg daily) and atorvastatin (40 mg daily). He r...

Cigarette smoking is associated with systemic oxidative stress leading to an upregulation of antioxidant systems [superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and heme oxygenase (HO)] in some tissues, but the response in the human placenta is unknown. The aim of this study was to determine the effect of cigarette smoke exposure on placental antioxidant expression in...

A trial of caspofungin salvage treatment in PCP pneumonia Pneumocystis jirovecii pneumonia (PCP) remains a major cause of mortality in patients with HIV; we read with enormous interest the recent PCP mortality prediction rule stratifying 451 patients by mortality at the time of illness presentation. The firstline treatment for this infection, cotrimoxazole, is associated with a number of advers...

Recent reports have demonstrated the capacity of bone marrow (BM) stem cells to transdifferentiate into hepatocytes. The efficiency of differentiation of bone marrow cells (BMC's) into hepatocytes in vivo and its importance in physiopathologic processes is still debated. The present study was designed to highlight part of the potential capabilities of bone marrow cells and their role in cell ba...