The apicomplexan Toxoplasma gondii (Nicolle et Manceaux, 1908) secretes a group of serine/threonine kinases from rhoptries, which play vital roles in boosting intracellular infection. rhoptry organelle protein 17 (ROP17) is one these important kinase proteins. Nevertheless, its function remains unclear. Here, we showed that ROP17 induced autophagy vitro and vivo. small intestine tissues T. tach...

Background: Salivary gland tumors are rare and with different malignant potential. Immunohistochemistry is useful, especially Ki67, a marker of cell proliferation, for its prognostic information. On the other side, mucin MUC-1 overexpressed loses exclusively apical membranous localization aberrantly glycosylated in mucoepidermoid carcinoma salivary glands. In present work, we investigated quant...

BACKGROUND Increased duodenal intraepithelial lymphocytes is a key histological finding in celiac disease. Available studies suggest a wide normal range (10 - 40 intraepithelial lymphocytes /100 epithelial cells, EC). We assessed the normal range of distal duodenal intraepithelial lymphocytes. METHODS Biopsies from the normal-looking distal duodenum from individuals referring for endoscopy fo...

Objective(s): The alteration of glucose transporters is closely related with the pathogenesis of brain edema. We compared neuronal damage/death in the hippocampus between adult and young gerbils following transient cerebral ischemia/reperfusion and changes of glucose transporter-1(GLUT-1)-immunoreactive microvessels in their ischemic hippocampal CA1 region. Materials and Methods: Transient cere...

Bovine viral diarrhoea virus (BVDV) infection is an important viral infection affecting the cattle industry today. The prevalence of this infection in South African feedlots is unknown. Ear notch biopsies were collected from chronic poor doers and animals that appeared unthrifty upon entering feedlots, as well as animals entering the hospital pen with respiratory disease for the first time....

Abstract Objectives Programmed death ligand-1 (PD-L1) expression in malignant epithelial neoplasms has been the subject of numerous studies; however, less data on its application to sarcomas are available. This research focused PD-L1 and how it correlated with clinicopathological characteristics soft tissue sarcomas. Materials Methods The anti-PD-L1 antibody Ki-67 were stained 50 cases sarcoma ...

objective(s): this study aims to determine the effects of ozone therapy on restoring impaired nrf2 activation to ameliorate chronic tubulointerstitial injury in rats with adenine-induced ckd. materials and methods: sprague–dawley rats were fed with 0.75% adenine-containing diet to induce ckd and chronic tubulointerstitial injury. ozone therapy was administered by rectal insufflation. after 4 we...

Langerhans cell neoplasms, which include histiocytosis and sarcoma, are tumors that originate from dendritic cells. sarcoma is defined as a high-grade neoplasm with overtly malignant cytological features the cell-like phenotype, generally has poorer prognosis more aggressive phenotype than histiocytosis. Insulin-like growth factor 2 messenger RNA-binding protein 3 (IGF2BP3 or IMP3) an oncofetal...

PURPOSE The purpose of our study was to investigate alterations in the meibomian gland (MG) in Cu, Zn-Superoxide Dismutase-1 knockout (Sod1-/-) mouse. METHODS Tear function tests [Break up time (BUT) and cotton thread] and ocular vital staining test were performed on Sod1-/- male mice (n = 24) aged 10 and 50 weeks, and age and sex matched wild-type (+/+) mice (n = 25). Tear and serum samples ...