Awareness that advancing cancer is often accompanied by defective imnmnologic responses, and accumulating evidence that immune reactions may influenee the course of cancer, has stimulated the study of various meehanisms of immunologic reaction in patients with cancer. As part of such a program we have determined the serum level of the second component of complement in a group of cancer patients...

Both divinyl benzene copolymer (plastic) beads and schistosome eggs produce inflammatory reactions after intravenous deposition into the lung of a mouse. As reported previously, the schistosome egg granuloma is an immunologic reaction of the delayed hypersensitivity type; this inflammatory process is prevented by immunosuppressive measures, and characteristically demonstrates an anamnestic resp...

The purpose of this study was to determine the toxicity profile of dendritic cell (DC) vaccination in stage III and IV melanoma patients, and to evaluate whether there is a correlation between side effects and immunologic and clinical outcome. This is a retrospective analysis of 82 stage III and 137 stage IV melanoma patients, vaccinated with monocyte-derived or naturally circulating autologous...

Breast augmentation with cadaveric fat graft has long been available to patients in Eastern European countries, primarily in the Soviet Union and Eastern Germany. Most such procedures were performed from the 1970s to the 1990s. Although only a few case reports have been published, all of which involved complications that appeared several years after the procedure, it appears that, surprisingly,...

Immunochemical techniques have been used extensively in studies on the chemistry and metabolism of serum lipoproteins. Several investigators (1-8) have produced antibodies against normal human lipoproteins by the injection of purified lipoproteins into rabbits, or into chickens (9). The antigen-antibody reaction between lipoproteins and their antisera has been demonstrated by precipitation (1-3...

cow’s milk allergy (cma) is the most frequent food allergy in children and oral immunotherapy (oit) is a promising approach for treatment of patients. the most challenging cases are anaphylactic with coexisting asthma and proposing safe protocols is crucial especially in high risk groups. considering that cma varies among patients, an individualized oit protocol would be beneficial to achieve a...

cytotoxic effects of obturation materials were tested in presence and absence of endotoxin on human monocytes in vitro.human monocytes from thp-1 cell line were cultured. three millimeters from the tip of each resilon and gutta percha points were cut and directly placed at the bottom of the culture wells. cultured cells were exposed to gutta percha (groups g1 and g2) and resilon (r1 and r2). te...

Immunologic processes in diseased human skin have been extensively investigated, but little is known about the effect of skin diseases on human afferent skin lymph. Starting in the papillary dermis, the skin lymphatics drain the adjacent tissue in a one-way flow toward the regional lymph nodes. The composition of the afferent lymph, therefore, reflects the immunologic inflammatory processes in ...

Progress in leprosy research was very restricted until recently, for it was, and still is, impossible to grow the causative organism M ycohacterium leprae in vitro. The work of Shepard (Ii) , however, opened up new possibilities, for he demonstrated that M. leprae can be grown in the footpads of mice. Rces and Weddell (2,3) and colleagues have further contributed to experimental leprosy in mice...

Although Schistosoma japonicum egg granulomas are generally considered to be similar to those of S. mansoni (which are largely immunologic reactions of the delayed hypersensitivity type) there are suggestions that the histopathology and perhaps the etiology of the lesions are different. In mice with light S. japonicum infections, at 5 weeks after infection (2 weeks after egg production began), ...